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CHEBI:78843 - CK-666

ChEBI IDCHEBI:78843
ChEBI NameCK-666
Stars
DefinitionA member of the class of indoles that is 2-methyltryptamine in which a hydrogen attached to the primary amino group has been replaced by a 2-fluorobenzoyl group. It is a cell-permeable inhibitor of actin assembly mediated by actin-related protein Arp2/3 complex which works by binding to Arp2/3 complex, stabilising the inactive state of the complex and preventing its movement into the active conformation.
Last Modified11 June 2021
SubmitterGareth Owen
DownloadsMolfile
FormulaC18H17FN2O
Net Charge0
Average Mass296.345
Monoisotopic Mass296.13249
SMILESCc1nc2ccccc2c1CCNC(=O)c1ccccc1F
InChIInChI=1S/C18H17FN2O/c1-12-13(14-6-3-5-9-17(14)21-12)10-11-20-18(22)15-7-2-4-8-16(15)19/h2-9,21H,10-11H2,1H3,(H,20,22)
InChIKeyUXRKUKRXVWJFER-UHFFFAOYSA-N
Roles Classification
Biological Role:
actin polymerisation inhibitor  Any substance that inhibits the polymerisation of the protein actin.
ChEBI Ontology
Outgoing Relation(s)
CK-666 (CHEBI:78843) has role actin polymerisation inhibitor (CHEBI:70728)
CK-666 (CHEBI:78843) is a benzamides (CHEBI:22702)
CK-666 (CHEBI:78843) is a indoles (CHEBI:24828)
CK-666 (CHEBI:78843) is a organofluorine compound (CHEBI:37143)
IUPAC Name 
2-fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide
Synonyms  Source
CK666ChEBI
CK 666ChEBI
CK-0944666ChEBI
Manual XrefsDatabases
CKHPDBeChem
Registry NumbersSources
Reaxys:19720234Reaxys
Citations