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CHEBI:76274 - SC560

Default Structure
ChEBI IDCHEBI:76274
ChEBI NameSC560
Stars
DefinitionA member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3 and 5 by 4-methoxyphenyl, trifluoromethyl and 4-chlorophenyl groups, respectively. Unlike many members of the diaryl heterocycle class of cyclooxygenase (COX) inhibitors, SC-560 is selective for COX-1.
Last Modified21 April 2016
SubmitterSteve
DownloadsMolfile
FormulaC17H12ClF3N2O
Net Charge0
Average Mass352.743
Monoisotopic Mass352.05903
SMILESCOc1ccc(-n2nc(C(F)(F)F)cc2-c2ccc(Cl)cc2)cc1
InChIInChI=1S/C17H12ClF3N2O/c1-24-14-8-6-13(7-9-14)23-15(10-16(22-23)17(19,20)21)11-2-4-12(18)5-3-11/h2-10H,1H3
InChIKeyPQUGCKBLVKJMNT-UHFFFAOYSA-N
Roles Classification
Biological Roles:
cyclooxygenase 1 inhibitor  A cyclooxygenase inhibitor that interferes with the action of cyclooxygenase 1.
apoptosis inducer  Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
Applications:
angiogenesis modulating agent  An agent that modulates the physiologic angiogenesis process. This is accomplished by endogenous angiogenic proteins and a variety of other chemicals and pharmaceutical agents.
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
non-steroidal anti-inflammatory drug  An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
ChEBI Ontology
Outgoing Relation(s)
SC560 (CHEBI:76274) has role angiogenesis modulating agent (CHEBI:50926)
SC560 (CHEBI:76274) has role antineoplastic agent (CHEBI:35610)
SC560 (CHEBI:76274) has role apoptosis inducer (CHEBI:68495)
SC560 (CHEBI:76274) has role cyclooxygenase 1 inhibitor (CHEBI:50630)
SC560 (CHEBI:76274) has role non-steroidal anti-inflammatory drug (CHEBI:35475)
SC560 (CHEBI:76274) is a aromatic ether (CHEBI:35618)
SC560 (CHEBI:76274) is a monochlorobenzenes (CHEBI:83403)
SC560 (CHEBI:76274) is a organofluorine compound (CHEBI:37143)
SC560 (CHEBI:76274) is a pyrazoles (CHEBI:26410)
IUPAC Name 
5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole
Synonyms  Source
5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-trifluoromethylpyrazoleChemIDplus
SC 560ChEBI
SC-560ChEBI
Manual XrefsDatabases
LSM-2314LINCS
WO2008076703Patent
Registry NumbersSources
Reaxys:7719788Reaxys
CAS:188817-13-2ChemIDplus
Citations