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CHEBI:76274 - SC560

ChEBI IDCHEBI:76274
ChEBI NameSC560
Stars
DefinitionA member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3 and 5 by 4-methoxyphenyl, trifluoromethyl and 4-chlorophenyl groups, respectively. Unlike many members of the diaryl heterocycle class of cyclooxygenase (COX) inhibitors, SC-560 is selective for COX-1.
Last Modified21 April 2016
SubmitterSteve
DownloadsMolfile
FormulaC17H12ClF3N2O
Net Charge0
Average Mass352.743
Monoisotopic Mass352.05903
SMILESCOc1ccc(-n2nc(C(F)(F)F)cc2-c2ccc(Cl)cc2)cc1
InChIInChI=1S/C17H12ClF3N2O/c1-24-14-8-6-13(7-9-14)23-15(10-16(22-23)17(19,20)21)11-2-4-12(18)5-3-11/h2-10H,1H3
InChIKeyPQUGCKBLVKJMNT-UHFFFAOYSA-N
Roles Classification
Biological Roles:
apoptosis inducer  Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
cyclooxygenase 1 inhibitor  A cyclooxygenase inhibitor that interferes with the action of cyclooxygenase 1.
Applications:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
non-steroidal anti-inflammatory drug  An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
angiogenesis modulating agent  An agent that modulates the physiologic angiogenesis process. This is accomplished by endogenous angiogenic proteins and a variety of other chemicals and pharmaceutical agents.
ChEBI Ontology
Outgoing Relation(s)
SC560 (CHEBI:76274) has role angiogenesis modulating agent (CHEBI:50926)
SC560 (CHEBI:76274) has role antineoplastic agent (CHEBI:35610)
SC560 (CHEBI:76274) has role apoptosis inducer (CHEBI:68495)
SC560 (CHEBI:76274) has role cyclooxygenase 1 inhibitor (CHEBI:50630)
SC560 (CHEBI:76274) has role non-steroidal anti-inflammatory drug (CHEBI:35475)
SC560 (CHEBI:76274) is a aromatic ether (CHEBI:35618)
SC560 (CHEBI:76274) is a monochlorobenzenes (CHEBI:83403)
SC560 (CHEBI:76274) is a organofluorine compound (CHEBI:37143)
SC560 (CHEBI:76274) is a pyrazoles (CHEBI:26410)
IUPAC Name 
5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole
Synonyms  Source
SC 560ChEBI
SC-560ChEBI
5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-trifluoromethylpyrazoleChemIDplus
Manual XrefsDatabases
WO2008076703Patent
LSM-2314LINCS
Registry NumbersSources
Reaxys:7719788Reaxys
CAS:188817-13-2ChemIDplus
Citations