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CHEBI:76232 - sodium meclofenamate monohydrate
| Formula | C14H10Cl2NO2.H2O.Na |
| Net Charge | 0 |
| Average Mass | 336.150 |
| Monoisotopic Mass | 335.00919 |
| SMILES | Cc1ccc(Cl)c(Nc2ccccc2C(=O)[O-])c1Cl.O.[Na+] |
| InChI | InChI=1S/C14H11Cl2NO2.Na.H2O/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19;;/h2-7,17H,1H3,(H,18,19);;1H2/q;+1;/p-1 |
| InChIKey | QHJLLDJTVQAFAN-UHFFFAOYSA-M |
| Roles Classification |
|---|
| Biological Roles: | EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor A lipoxygenase inhibitor that interferes with the action of arachidonate 5-lipoxygenase (EC 1.13.11.34). EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor A compound or agent that combines with cyclooxygenases (EC 1.14.99.1) and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of icosanoids, prostaglandins, and thromboxanes. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. |
| Applications: | antipyretic A drug that prevents or reduces fever by lowering the body temperature from a raised state. An antipyretic will not affect the normal body temperature if one does not have fever. Antipyretics cause the hypothalamus to override an interleukin-induced increase in temperature. The body will then work to lower the temperature and the result is a reduction in fever. non-steroidal anti-inflammatory drug An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. antirheumatic drug A drug used to treat rheumatoid arthritis. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. anticonvulsant A drug used to prevent seizures or reduce their severity. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| sodium meclofenamate monohydrate (CHEBI:76232) has part sodium meclofenamate (anhydrous) (CHEBI:6711) |
| sodium meclofenamate monohydrate (CHEBI:76232) has role analgesic (CHEBI:35480) |
| sodium meclofenamate monohydrate (CHEBI:76232) has role anticonvulsant (CHEBI:35623) |
| sodium meclofenamate monohydrate (CHEBI:76232) has role antineoplastic agent (CHEBI:35610) |
| sodium meclofenamate monohydrate (CHEBI:76232) has role antipyretic (CHEBI:35493) |
| sodium meclofenamate monohydrate (CHEBI:76232) has role antirheumatic drug (CHEBI:35842) |
| sodium meclofenamate monohydrate (CHEBI:76232) has role EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor (CHEBI:64964) |
| sodium meclofenamate monohydrate (CHEBI:76232) has role EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor (CHEBI:35544) |
| sodium meclofenamate monohydrate (CHEBI:76232) has role non-steroidal anti-inflammatory drug (CHEBI:35475) |
| sodium meclofenamate monohydrate (CHEBI:76232) is a hydrate (CHEBI:35505) |
| Synonyms | Source |
|---|---|
| sodium meclofenamate | ChemIDplus |
| meclofenamate sodium | ChemIDplus |
| Brand Names | Source |
|---|---|
| Lenidolor | ChEBI |
| Meclodol | ChEBI |
| Meclomen | KEGG DRUG |
| Manual Xrefs | Databases |
|---|---|
| D00169 | KEGG DRUG |
| Registry Numbers | Sources |
|---|---|
| Reaxys:14619562 | Reaxys |
| CAS:67254-91-5 | ChemIDplus |
| Citations |
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