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CHEBI:76172 - loxoprofen
| Formula | C15H18O3 |
| Net Charge | 0 |
| Average Mass | 246.306 |
| Monoisotopic Mass | 246.12559 |
| SMILES | CC(C(=O)O)c1ccc(CC2CCCC2=O)cc1 |
| InChI | InChI=1S/C15H18O3/c1-10(15(17)18)12-7-5-11(6-8-12)9-13-3-2-4-14(13)16/h5-8,10,13H,2-4,9H2,1H3,(H,17,18) |
| InChIKey | YMBXTVYHTMGZDW-UHFFFAOYSA-N |
| Wikipedia |
|---|
| Roles Classification |
|---|
| Chemical Role: | Bronsted acid A molecular entity capable of donating a hydron to an acceptor (Brønsted base). |
| Biological Roles: | analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. non-narcotic analgesic A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors. EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor A compound or agent that combines with cyclooxygenases (EC 1.14.99.1) and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of icosanoids, prostaglandins, and thromboxanes. |
| Applications: | non-steroidal anti-inflammatory drug An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. antirheumatic drug A drug used to treat rheumatoid arthritis. antipyretic A drug that prevents or reduces fever by lowering the body temperature from a raised state. An antipyretic will not affect the normal body temperature if one does not have fever. Antipyretics cause the hypothalamus to override an interleukin-induced increase in temperature. The body will then work to lower the temperature and the result is a reduction in fever. non-narcotic analgesic A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors. prodrug A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| loxoprofen (CHEBI:76172) has functional parent propionic acid (CHEBI:30768) |
| loxoprofen (CHEBI:76172) has role analgesic (CHEBI:35480) |
| loxoprofen (CHEBI:76172) has role antipyretic (CHEBI:35493) |
| loxoprofen (CHEBI:76172) has role antirheumatic drug (CHEBI:35842) |
| loxoprofen (CHEBI:76172) has role EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor (CHEBI:35544) |
| loxoprofen (CHEBI:76172) has role non-narcotic analgesic (CHEBI:35481) |
| loxoprofen (CHEBI:76172) has role non-steroidal anti-inflammatory drug (CHEBI:35475) |
| loxoprofen (CHEBI:76172) has role prodrug (CHEBI:50266) |
| loxoprofen (CHEBI:76172) is a cyclopentanones (CHEBI:36140) |
| loxoprofen (CHEBI:76172) is a monocarboxylic acid (CHEBI:25384) |
| loxoprofen (CHEBI:76172) is conjugate acid of loxoprofen(1−) (CHEBI:76199) |
| Incoming Relation(s) |
| (2S)-2-(4-{[(1R,2S)-2-hydroxycyclopentyl]methyl}phenyl)propanoic acid (CHEBI:76204) has functional parent loxoprofen (CHEBI:76172) |
| loxoprofen(1−) (CHEBI:76199) is conjugate base of loxoprofen (CHEBI:76172) |
| IUPAC Name |
|---|
| 2-{4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid |
| INNs | Source |
|---|---|
| loxoprofen | KEGG DRUG |
| loxoprofene | ChemIDplus |
| loxoprofeno | ChemIDplus |
| loxoprofenum | ChemIDplus |
| Synonyms | Source |
|---|---|
| (±)-((2-oxocyclopentyl)methyl)hydratropic acid | ChemIDplus |
| Loxoprofen acid | ChEMBL |
| Manual Xrefs | Databases |
|---|---|
| 1615 | DrugCentral |
| D08149 | KEGG DRUG |
| EP1767218 | Patent |
| HMDB0041920 | HMDB |
| Loxoprofen | Wikipedia |
| LSM-5054 | LINCS |
| WO2008020270 | Patent |
| Registry Numbers | Sources |
|---|---|
| Reaxys:2860055 | Reaxys |
| CAS:68767-14-6 | ChemIDplus |
| CAS:68767-14-6 | KEGG DRUG |
| Citations |
|---|