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CHEBI:76164 - lonazolac

ChEBI IDCHEBI:76164
ChEBI Namelonazolac
Stars
DefinitionA monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is replaced by a 3-(4-chlorophenyl)-1-phenylpyrazol-4-yl group.
Last Modified22 February 2017
SubmitterSteve
DownloadsMolfile
FormulaC17H13ClN2O2
Net Charge0
Average Mass312.756
Monoisotopic Mass312.06656
SMILESO=C(O)Cc1cn(-c2ccccc2)nc1-c1ccc(Cl)cc1
InChIInChI=1S/C17H13ClN2O2/c18-14-8-6-12(7-9-14)17-13(10-16(21)22)11-20(19-17)15-4-2-1-3-5-15/h1-9,11H,10H2,(H,21,22)
InChIKeyXVUQHFRQHBLHQD-UHFFFAOYSA-N
Wikipedia
Roles Classification
Chemical Role:
Bronsted acid  A molecular entity capable of donating a hydron to an acceptor (Brønsted base).
Biological Roles:
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor  A compound or agent that combines with cyclooxygenases (EC 1.14.99.1) and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of icosanoids, prostaglandins, and thromboxanes.
non-narcotic analgesic  A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
Applications:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
non-steroidal anti-inflammatory drug  An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
non-narcotic analgesic  A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
ChEBI Ontology
Outgoing Relation(s)
lonazolac (CHEBI:76164) has functional parent acetic acid (CHEBI:15366)
lonazolac (CHEBI:76164) has role antineoplastic agent (CHEBI:35610)
lonazolac (CHEBI:76164) has role EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor (CHEBI:35544)
lonazolac (CHEBI:76164) has role non-narcotic analgesic (CHEBI:35481)
lonazolac (CHEBI:76164) has role non-steroidal anti-inflammatory drug (CHEBI:35475)
lonazolac (CHEBI:76164) is a monocarboxylic acid (CHEBI:25384)
lonazolac (CHEBI:76164) is a monochlorobenzenes (CHEBI:83403)
lonazolac (CHEBI:76164) is a pyrazoles (CHEBI:26410)
lonazolac (CHEBI:76164) is conjugate acid of lonazolac(1−) (CHEBI:76169)
Incoming Relation(s)
lonazolac(1−) (CHEBI:76169) is conjugate base of lonazolac (CHEBI:76164)
IUPAC Name 
[3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]acetic acid
INNs  Source
lonazolacKEGG DRUG
lonazolacWHO MedNet
lonazolacoChemIDplus
lonazolacumChemIDplus
Synonym  Source
3-(p-Chlorophenyl)-1-phenylpyrazole-4-acetic acidChemIDplus
Manual XrefsDatabases
1597DrugCentral
D07265KEGG DRUG
LonazolacWikipedia
WO2008017903Patent
Registry NumbersSources
CAS:53808-88-1ChemIDplus
CAS:53808-88-1KEGG DRUG
Citations