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CHEBI:76144 - flunixin meglumine

ChEBI IDCHEBI:76144
ChEBI Nameflunixin meglumine
Stars
DefinitionAn organoammonium salt obtained by combining flunixin with one molar equivalent of 1-deoxy-1-(methylamino)-D-glucitol. A relatively potent non-narcotic, nonsteroidal analgesic with anti-inflammatory, anti-endotoxic and anti-pyretic properties; used in veterinary medicine for treatment of horses, cattle and pigs.
Last Modified22 July 2014
SubmitterSteve
DownloadsMolfile
FormulaC14H11F3N2O2.C7H17NO5
Net Charge0
Average Mass491.463
Monoisotopic Mass491.18793
SMILESCNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.Cc1c(Nc2ncccc2C(=O)O)cccc1C(F)(F)F
InChIInChI=1S/C14H11F3N2O2.C7H17NO5/c1-8-10(14(15,16)17)5-2-6-11(8)19-12-9(13(20)21)4-3-7-18-12;1-8-2-4(10)6(12)7(13)5(11)3-9/h2-7H,1H3,(H,18,19)(H,20,21);4-13H,2-3H2,1H3/t;4-,5+,6+,7+/m.0/s1
InChIKeyMGCCHNLNRBULBU-WZTVWXICSA-N
Wikipedia
Roles Classification
Biological Roles:
non-narcotic analgesic  A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor  A compound or agent that combines with cyclooxygenases (EC 1.14.99.1) and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of icosanoids, prostaglandins, and thromboxanes.
Applications:
antipyretic  A drug that prevents or reduces fever by lowering the body temperature from a raised state. An antipyretic will not affect the normal body temperature if one does not have fever. Antipyretics cause the hypothalamus to override an interleukin-induced increase in temperature. The body will then work to lower the temperature and the result is a reduction in fever.
non-narcotic analgesic  A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
non-steroidal anti-inflammatory drug  An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
ChEBI Ontology
Outgoing Relation(s)
flunixin meglumine (CHEBI:76144) has part flunixin(1−) (CHEBI:76153)
flunixin meglumine (CHEBI:76144) has role antipyretic (CHEBI:35493)
flunixin meglumine (CHEBI:76144) has role EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor (CHEBI:35544)
flunixin meglumine (CHEBI:76144) has role non-narcotic analgesic (CHEBI:35481)
flunixin meglumine (CHEBI:76144) has role non-steroidal anti-inflammatory drug (CHEBI:35475)
flunixin meglumine (CHEBI:76144) is a organoammonium salt (CHEBI:46850)
IUPAC Names 
2-{[2-methyl-3-(trifluoromethyl)phenyl]amino}nicotinic acid—1-deoxy-1-(methylamino)-D-glucitol (1/1)
1-deoxy-1-(methylazaniumyl)-D-glucitol 2-{[2-methyl-3-(trifluoromethyl)phenyl]amino}nicotinate
Synonyms  Source
Flunixin-SChemIDplus
1-Deoxy-1-(methylamino)-D-glucitol 2-(2-methyl-3-(perfluoromethyl)anilino)nicotinateChemIDplus
FlumeglumineChemIDplus
Flunixin N-methylglucanineChemIDplus
Brand Name  Source
BanamineChemIDplus
Manual XrefsDatabases
D04216KEGG DRUG
US2008153885Patent
FlunixinWikipedia
Registry NumbersSources
Reaxys:8888607Reaxys
CAS:42461-84-7KEGG DRUG
CAS:42461-84-7ChemIDplus
Citations