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CHEBI:760578 - YTX-465

Default Structure
ChEBI IDCHEBI:760578
ChEBI NameYTX-465
Stars
DefinitionA 1,2,4-oxadiazole substituted by 1,3-dimethyl-1H-indazol-6-yl and 1-(benzamidoacetyl)piperidin-4-yl groups at positions 3 and 5, respectively. It is an inhibitor of stearoyl-CoA desaturase and has been investigated as a potential therapeutic agent in Parkinson’s disease and other synucleinopathies.
Last Modified1 September 2026
Submitterrnash
DownloadsMolfile
FormulaC25H26N6O3
Net Charge0
Average Mass458.522
Monoisotopic Mass458.20664
SMILESCc1nn(C)c2cc(-c3noc(C4CCN(C(=O)CNC(=O)c5ccccc5)CC4)n3)ccc12
InChIInChI=1S/C25H26N6O3/c1-16-20-9-8-19(14-21(20)30(2)28-16)23-27-25(34-29-23)18-10-12-31(13-11-18)22(32)15-26-24(33)17-6-4-3-5-7-17/h3-9,14,18H,10-13,15H2,1-2H3,(H,26,33)
InChIKeyUNYSKYOVUXWBJG-UHFFFAOYSA-N
Roles Classification
Chemical Role:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Role:
EC 1.14.19.1 (stearoyl-CoA 9-desaturase) inhibitor  An EC 1.14.19.* (oxidoreductase acting on paired donors, with incorporation of one atom each of oxygen into both donors, with 2-oxoglutarate as one donor) inhibitor that interferes with the action of stearoyl-CoA 9-desaturase (EC 1.14.19.1).
ChEBI Ontology
Outgoing Relation(s)
YTX-465 (CHEBI:760578) has role EC 1.14.19.1 (stearoyl-CoA 9-desaturase) inhibitor (CHEBI:760800)
YTX-465 (CHEBI:760578) is a N-acylpiperidine (CHEBI:48591)
YTX-465 (CHEBI:760578) is a 1,2,4-oxadiazole (CHEBI:46809)
YTX-465 (CHEBI:760578) is a benzamides (CHEBI:22702)
YTX-465 (CHEBI:760578) is a indazoles (CHEBI:38769)
YTX-465 (CHEBI:760578) is a secondary carboxamide (CHEBI:140325)
YTX-465 (CHEBI:760578) is a tertiary amino compound (CHEBI:50996)
YTX-465 (CHEBI:760578) is a tertiary carboxamide (CHEBI:140326)
IUPAC Name 
N-(2-{4-[3-(1,3-dimethyl-1H-indazol-6-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl}-2-oxoethyl)benzamide
Synonyms  Source
N-[2-[4-[3-(1,3-dimethyl-1H-indazol-6-yl)-1,2,4-oxadiazol-5-yl]-1-piperidinyl]-2-oxoethyl]benzamideCAS
N-(2-(4-(3-(1,3-dimethyl-1H-indazol-6-yl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)-2-oxoethyl)benzamideChEBI
N-[2-[4-[3-(1,3-dimethylindazol-6-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]-2-oxoethyl]benzamideChEBI
YTX 465ChEBI
YTX465ChEBI
Registry NumbersSources
CAS:2225824-53-1CAS
Citations