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CHEBI:75998 - trametinib

ChEBI IDCHEBI:75998
ChEBI Nametrametinib
Stars
DefinitionA pyridopyrimidine that is used (as its dimethyl sulfoxide addition compound) for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E or V600K mutations, and who have not received prior BRAF inhibitor treatment.
Last Modified5 October 2021
SubmitterSteve
DownloadsMolfile

FormulaC26H23FIN5O4
Net Charge0
Average Mass615.403
Monoisotopic Mass615.07788
SMILESCC(=O)Nc1cccc(-n2c(=O)n(C3CC3)c(=O)c3c(Nc4ccc(I)cc4F)n(C)c(=O)c(C)c32)c1
InChIInChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34)
InChIKeyLIRYPHYGHXZJBZ-UHFFFAOYSA-N

Wikipedia
Roles Classification

ChEBI Ontology
IUPAC Name 
N-(3-{3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide
INNs  Source
trametinib  esWHO MedNet
trametinibWHO MedNet
tramétinib  frWHO MedNet
trametinibum  laWHO MedNet
Synonyms  Source
GSK 1120212ChemIDplus
JTP 74057ChemIDplus
Manual XrefsDatabases
D10175KEGG DRUG
DB08911DrugBank
WO2005121142Patent
WO2011047238Patent
WO2011038085Patent
WO2011038082Patent
TrametinibWikipedia
LSM-1143LINCS
4802DrugCentral
9881833ChemSpider
Registry NumbersSources
Reaxys:12497153Reaxys
CAS:871700-17-3KEGG COMPOUND
CAS:871700-17-3ChemIDplus
Citations