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CHEBI:7582 - nitrendipine

ChEBI IDCHEBI:7582
ChEBI Namenitrendipine
Stars
DefinitionA dihydropyridine that is 1,4-dihydropyridine substituted by methyl groups at positions 2 and 6, a 3-nitrophenyl group at position 4, a ethoxycarbonyl group at position 3 and a methoxycarbonyl group at position 5. It is a calcium-channel blocker used in the treatment of hypertension.
Last Modified26 October 2021
DownloadsMolfile
FormulaC18H20N2O6
Net Charge0
Average Mass360.366
Monoisotopic Mass360.13214
SMILESCCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1cccc([N+](=O)[O-])c1
InChIInChI=1S/C18H20N2O6/c1-5-26-18(22)15-11(3)19-10(2)14(17(21)25-4)16(15)12-7-6-8-13(9-12)20(23)24/h6-9,16,19H,5H2,1-4H3
InChIKeyPVHUJELLJLJGLN-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Role:
calcium channel blocker  One of a class of drugs that acts by selective inhibition of calcium influx through cell membranes or on the release and binding of calcium in intracellular pools.
Applications:
antihypertensive agent  Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
vasodilator agent  A drug used to cause dilation of the blood vessels.
geroprotector  Any compound that supports healthy aging, slows the biological aging process, or extends lifespan.
ChEBI Ontology
Outgoing Relation(s)
nitrendipine (CHEBI:7582) has role antihypertensive agent (CHEBI:35674)
nitrendipine (CHEBI:7582) has role calcium channel blocker (CHEBI:38215)
nitrendipine (CHEBI:7582) has role geroprotector (CHEBI:176497)
nitrendipine (CHEBI:7582) has role vasodilator agent (CHEBI:35620)
nitrendipine (CHEBI:7582) is a C-nitro compound (CHEBI:35716)
nitrendipine (CHEBI:7582) is a dicarboxylic acids and O-substituted derivatives (CHEBI:131927)
nitrendipine (CHEBI:7582) is a diester (CHEBI:51307)
nitrendipine (CHEBI:7582) is a dihydropyridine (CHEBI:50075)
nitrendipine (CHEBI:7582) is a ethyl ester (CHEBI:23990)
nitrendipine (CHEBI:7582) is a methyl ester (CHEBI:25248)
IUPAC Name 
ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
INNs  Source
nitrendipinoChemIDplus
nitrendipineChemIDplus
nitrendipinumChemIDplus
Synonyms  Source
1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl esterChemIDplus
BAY e 5009ChemIDplus
Brand Names  Source
BaypressKEGG DRUG
DeitenChEBI
NidrelChemIDplus
BylotensinChEBI
BayotensinChemIDplus
Manual XrefsDatabases
C07713KEGG COMPOUND
D00629KEGG DRUG
HMDB0015187HMDB
NitrendipineWikipedia
DB01054DrugBank
CN101416954Patent
DE2117571Patent
US3799934Patent
LSM-1246LINCS
1947DrugCentral
Registry NumbersSources
Reaxys:498823Reaxys
CAS:39562-70-4KEGG COMPOUND
CAS:39562-70-4NIST Chemistry WebBook
Citations