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CHEBI:7577 - nisoldipine
| ChEBI ID | CHEBI:7577 |
| ChEBI Name | nisoldipine |
| Stars | |
| Definition | A racemate consisting of equimolar amounts of (R)- and (S)-nisoldipine. A calcium channel blocker, it is used in the treatment of hypertension and angina pectoris. |
| Last Modified | 21 April 2017 |
| Wikipedia |
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| Roles Classification |
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| Biological Role: | calcium channel blocker One of a class of drugs that acts by selective inhibition of calcium influx through cell membranes or on the release and binding of calcium in intracellular pools. |
| Applications: | platelet aggregation inhibitor A drug or agent which antagonizes or impairs any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system. cardiovascular drug A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume. antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. vasodilator agent A drug used to cause dilation of the blood vessels. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| nisoldipine (CHEBI:7577) has part (R)-nisoldipine (CHEBI:76918) |
| nisoldipine (CHEBI:7577) has part (S)-nisoldipine (CHEBI:76919) |
| nisoldipine (CHEBI:7577) has role antihypertensive agent (CHEBI:35674) |
| nisoldipine (CHEBI:7577) has role calcium channel blocker (CHEBI:38215) |
| nisoldipine (CHEBI:7577) has role cardiovascular drug (CHEBI:35554) |
| nisoldipine (CHEBI:7577) has role platelet aggregation inhibitor (CHEBI:50427) |
| nisoldipine (CHEBI:7577) has role vasodilator agent (CHEBI:35620) |
| nisoldipine (CHEBI:7577) is a racemate (CHEBI:60911) |
| IUPAC Name |
|---|
| rac-methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate |
| INNs | Source |
|---|---|
| nisoldipine | WHO MedNet |
| nisoldipine | KEGG DRUG |
| nisoldipino | ChemIDplus |
| nisoldipinum | ChemIDplus |
| Synonyms | Source |
|---|---|
| 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid methyl 2-methylpropyl ester | NIST Chemistry WebBook |
| (±)-isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(o-nitrophenyl)-3,5-pyridinedicarboxylate | ChemIDplus |
| Brand Names | Source |
|---|---|
| Baymycard | DrugBank |
| Sular | KEGG DRUG |
| Syscor | DrugBank |
| Zadipina | DrugBank |
| Manual Xrefs | Databases |
|---|---|
| C07699 | KEGG COMPOUND |
| D00618 | KEGG DRUG |
| DB00401 | DrugBank |
| DE2549568 | Patent |
| HMDB0014545 | HMDB |
| Nisoldipine | Wikipedia |
| US4154839 | Patent |
| Registry Numbers | Sources |
|---|---|
| Reaxys:454188 | Reaxys |
| CAS:63675-72-9 | KEGG COMPOUND |
| CAS:63675-72-9 | ChemIDplus |
| CAS:63675-72-9 | NIST Chemistry WebBook |
| Citations |
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