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CHEBI:7577 - nisoldipine
| ChEBI ID | CHEBI:7577 |
| ChEBI Name | nisoldipine |
| Stars | |
| Definition | A racemate consisting of equimolar amounts of (R)- and (S)-nisoldipine. A calcium channel blocker, it is used in the treatment of hypertension and angina pectoris. |
| Last Modified | 21 April 2017 |
| Wikipedia |
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| Roles Classification |
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| Biological Role: | calcium channel blocker One of a class of drugs that acts by selective inhibition of calcium influx through cell membranes or on the release and binding of calcium in intracellular pools. |
| Applications: | cardiovascular drug A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume. vasodilator agent A drug used to cause dilation of the blood vessels. antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. platelet aggregation inhibitor A drug or agent which antagonizes or impairs any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system. |
| ChEBI Ontology |
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| Outgoing Relation(s) |
| nisoldipine (CHEBI:7577) has part (R)-nisoldipine (CHEBI:76918) |
| nisoldipine (CHEBI:7577) has part (S)-nisoldipine (CHEBI:76919) |
| nisoldipine (CHEBI:7577) has role antihypertensive agent (CHEBI:35674) |
| nisoldipine (CHEBI:7577) has role calcium channel blocker (CHEBI:38215) |
| nisoldipine (CHEBI:7577) has role cardiovascular drug (CHEBI:35554) |
| nisoldipine (CHEBI:7577) has role platelet aggregation inhibitor (CHEBI:50427) |
| nisoldipine (CHEBI:7577) has role vasodilator agent (CHEBI:35620) |
| nisoldipine (CHEBI:7577) is a racemate (CHEBI:60911) |
| IUPAC Name |
|---|
| rac-methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate |
| INNs | Source |
|---|---|
| nisoldipine | KEGG DRUG |
| nisoldipinum | ChemIDplus |
| nisoldipino | ChemIDplus |
| nisoldipine | WHO MedNet |
| Synonyms | Source |
|---|---|
| (±)-isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(o-nitrophenyl)-3,5-pyridinedicarboxylate | ChemIDplus |
| 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid methyl 2-methylpropyl ester | NIST Chemistry WebBook |
| Brand Names | Source |
|---|---|
| Sular | KEGG DRUG |
| Baymycard | DrugBank |
| Syscor | DrugBank |
| Zadipina | DrugBank |
| Manual Xrefs | Databases |
|---|---|
| C07699 | KEGG COMPOUND |
| D00618 | KEGG DRUG |
| Nisoldipine | Wikipedia |
| DB00401 | DrugBank |
| DE2549568 | Patent |
| US4154839 | Patent |
| HMDB0014545 | HMDB |
| Registry Numbers | Sources |
|---|---|
| Reaxys:454188 | Reaxys |
| CAS:63675-72-9 | KEGG COMPOUND |
| CAS:63675-72-9 | ChemIDplus |
| CAS:63675-72-9 | NIST Chemistry WebBook |
| Citations |
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