tapotoclax (CHEBI:757677)

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CHEBI:757677 - tapotoclax

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ChEBI ID	CHEBI:757677
ChEBI Name	tapotoclax
Stars
Last Modified	30 June 2026
Submitter	ChEMBL
Downloads	Molfile

Formula	C33H41ClN2O5S
Net Charge	0
Average Mass	613.220
Monoisotopic Mass	612.24247
SMILES	[H][C@@]12CC[C@@]1([H])[C@@H](OC)/C=C/C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c1ccc3c(c1)N(C[C@@]1(CCCc4cc(Cl)ccc41)CO3)C2
InChI	InChI=1S/C33H41ClN2O5S/c1-21-6-4-8-30(40-3)27-12-9-25(27)18-36-19-33(15-5-7-23-16-26(34)11-13-28(23)33)20-41-31-14-10-24(17-29(31)36)32(37)35-42(38,39)22(21)2/h4,8,10-11,13-14,16-17,21-22,25,27,30H,5-7,9,12,15,18-20H2,1-3H3,(H,35,37)/b8-4+/t21-,22+,25-,27+,30-,33-/m0/s1
InChIKey	JQNINBDKGLWYMU-GEAQBIRJSA-N

Roles Classification

antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms.

ChEBI Ontology

Outgoing Relation(s)
	tapotoclax (CHEBI:757677) has role antineoplastic agent (CHEBI:35610)
	tapotoclax (CHEBI:757677) is a tetralins (CHEBI:36786)

INN	Source
tapotoclax	WHO MedNet

Synonyms	Source
AMG 176	ChEMBL
AMG-176	ChEMBL
AMG176	ChEMBL
Mcl-1 inhibitor amg 176	ChEMBL
Mcl-1 inhibitor amg-176	ChEMBL

Citations