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CHEBI:755703 - mk-8457

Default Structure
ChEBI IDCHEBI:755703
ChEBI Namemk-8457
Stars
Last Modified29 June 2026
SubmitterChEMBL
DownloadsMolfile
FormulaC24H25F3N4O3S
Net Charge0
Average Mass506.550
Monoisotopic Mass506.15995
SMILESCc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cnc([C@@]3(O)CC[C@H](C(=O)O)C(C)(C)C3)s2)c1
InChIInChI=1S/C24H25F3N4O3S/c1-13-8-14(10-15(9-13)30-21-28-7-5-18(31-21)24(25,26)27)17-11-29-20(35-17)23(34)6-4-16(19(32)33)22(2,3)12-23/h5,7-11,16,34H,4,6,12H2,1-3H3,(H,32,33)(H,28,30,31)/t16-,23-/m1/s1
InChIKeyLDDBKIFZPGDEND-WAIKUNEKSA-N
Roles Classification
Application:
antihypertensive agent  Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
ChEBI Ontology
Outgoing Relation(s)
mk-8457 (CHEBI:755703) has role antihypertensive agent (CHEBI:35674)
mk-8457 (CHEBI:755703) is a thiazoles (CHEBI:48901)
Synonym  Source
Mk-8457ChEMBL