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CHEBI:75404 - tyrphostin AG 1478

Default Structure
ChEBI IDCHEBI:75404
ChEBI Nametyrphostin AG 1478
Stars
DefinitionA member of the class of quinazolines that is quinazoline substituted by methoxy groups at positions 6 and 7 and a (3-chlorophenyl)nitrilo group at position 4. It acts as an epidermal growth factor receptor antagonist.
Last Modified27 October 2021
Submitternamrata
DownloadsMolfile
FormulaC16H14ClN3O2
Net Charge0
Average Mass315.760
Monoisotopic Mass315.07745
SMILESCOc1cc2ncnc(Nc3cccc(Cl)c3)c2cc1OC
InChIInChI=1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20)
InChIKeyGFNNBHLJANVSQV-UHFFFAOYSA-N
Roles Classification
Biological Roles:
antiviral agent  A substance that destroys or inhibits replication of viruses.
epidermal growth factor receptor antagonist  An antagonist at the epidermal growth factor receptor.
Applications:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
geroprotector  Any compound that supports healthy aging, slows the biological aging process, or extends lifespan.
ChEBI Ontology
Outgoing Relation(s)
tyrphostin AG 1478 (CHEBI:75404) has role antineoplastic agent (CHEBI:35610)
tyrphostin AG 1478 (CHEBI:75404) has role antiviral agent (CHEBI:22587)
tyrphostin AG 1478 (CHEBI:75404) has role epidermal growth factor receptor antagonist (CHEBI:74440)
tyrphostin AG 1478 (CHEBI:75404) has role geroprotector (CHEBI:176497)
tyrphostin AG 1478 (CHEBI:75404) is a aromatic ether (CHEBI:35618)
tyrphostin AG 1478 (CHEBI:75404) is a monochlorobenzenes (CHEBI:83403)
tyrphostin AG 1478 (CHEBI:75404) is a quinazolines (CHEBI:38530)
IUPAC Name 
N-(3-chlorophenyl)-6,7-dimethoxy-quinazolin-4-amine
Synonyms  Source
AG 1478ChemIDplus
AG-1478ChemIDplus
tyrphostin AG-1478ChEBI
Manual XrefsDatabases
0TOPDBeChem
LSM-1224LINCS
Registry NumbersSources
Reaxys:7437034Reaxys
CAS:170449-18-0ChemIDplus
Citations