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CHEBI:75404 - tyrphostin AG 1478

ChEBI IDCHEBI:75404
ChEBI Nametyrphostin AG 1478
Stars
DefinitionA member of the class of quinazolines that is quinazoline substituted by methoxy groups at positions 6 and 7 and a (3-chlorophenyl)nitrilo group at position 4. It acts as an epidermal growth factor receptor antagonist.
Last Modified27 October 2021
Submitternamrata
DownloadsMolfile
FormulaC16H14ClN3O2
Net Charge0
Average Mass315.760
Monoisotopic Mass315.07745
SMILESCOc1cc2ncnc(Nc3cccc(Cl)c3)c2cc1OC
InChIInChI=1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20)
InChIKeyGFNNBHLJANVSQV-UHFFFAOYSA-N
Roles Classification
Biological Roles:
epidermal growth factor receptor antagonist  An antagonist at the epidermal growth factor receptor.
antiviral agent  A substance that destroys or inhibits replication of viruses.
Applications:
geroprotector  Any compound that supports healthy aging, slows the biological aging process, or extends lifespan.
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
tyrphostin AG 1478 (CHEBI:75404) has role antineoplastic agent (CHEBI:35610)
tyrphostin AG 1478 (CHEBI:75404) has role antiviral agent (CHEBI:22587)
tyrphostin AG 1478 (CHEBI:75404) has role epidermal growth factor receptor antagonist (CHEBI:74440)
tyrphostin AG 1478 (CHEBI:75404) has role geroprotector (CHEBI:176497)
tyrphostin AG 1478 (CHEBI:75404) is a aromatic ether (CHEBI:35618)
tyrphostin AG 1478 (CHEBI:75404) is a monochlorobenzenes (CHEBI:83403)
tyrphostin AG 1478 (CHEBI:75404) is a quinazolines (CHEBI:38530)
IUPAC Name 
N-(3-chlorophenyl)-6,7-dimethoxy-quinazolin-4-amine
Synonyms  Source
AG 1478ChemIDplus
AG-1478ChemIDplus
tyrphostin AG-1478ChEBI
Manual XrefsDatabases
0TOPDBeChem
LSM-1224LINCS
Registry NumbersSources
Reaxys:7437034Reaxys
CAS:170449-18-0ChemIDplus
Citations