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CHEBI:75292 - phenanthridone

Default Structure
ChEBI IDCHEBI:75292
ChEBI Namephenanthridone
Stars
DefinitionA member of the class of phenanthridines that is phenanthridine with an oxo substituent at position 6. A poly(ADP-ribose) polymerase (PARP) inhibitor, it has been shown to exhibit immunosuppressive activity.
Last Modified24 February 2016
Submitternamrata
DownloadsMolfile
FormulaC13H9NO
Net Charge0
Average Mass195.221
Monoisotopic Mass195.06841
SMILESO=c1nc2ccccc2c2ccccc12
InChIInChI=1S/C13H9NO/c15-13-11-7-2-1-5-9(11)10-6-3-4-8-12(10)14-13/h1-8H,(H,14,15)
InChIKeyRZFVLEJOHSLEFR-UHFFFAOYSA-N
Roles Classification
Biological Roles:
immunosuppressive agent  An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response.
EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor  An EC 2.4.2.* (pentosyltransferase) inhibitor that interferes with the action of a NAD+ ADP-ribosyltransferase (EC 2.4.2.30).
mutagen  An agent that increases the frequency of mutations above the normal background level, usually by interacting directly with DNA and causing it damage, including base substitution.
Application:
immunosuppressive agent  An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response.
ChEBI Ontology
Outgoing Relation(s)
phenanthridone (CHEBI:75292) has role EC 2.4.2.30 (NAD+ ADP-ribosyltransferase) inhibitor (CHEBI:62913)
phenanthridone (CHEBI:75292) has role immunosuppressive agent (CHEBI:35705)
phenanthridone (CHEBI:75292) has role mutagen (CHEBI:25435)
phenanthridone (CHEBI:75292) is a lactam (CHEBI:24995)
phenanthridone (CHEBI:75292) is a phenanthridines (CHEBI:51245)
IUPAC Name 
phenanthridin-6(5H)-one
Synonyms  Source
6-PhenanthridinolChemIDplus
6-PhenanthridinoneChemIDplus
6-PhenanthridoneChemIDplus
Manual XrefsDatabases
LSM-2229LINCS
US2478805Patent
Registry NumbersSources
Reaxys:140641Reaxys
CAS:1015-89-0ChemIDplus
CAS:1015-89-0NIST Chemistry WebBook
Citations