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CHEBI:75272 - splitomicin

ChEBI IDCHEBI:75272
ChEBI Namesplitomicin
Stars
DefinitionA benzochromenone that is 2,3-dihydro-1H-benzo[f]chromene substituted by an oxo group at position 3. It has been found to exhibit potential inhibitory activity against Sir2 proteins.
Last Modified9 March 2020
Submitternamrata
DownloadsMolfile
FormulaC13H10O2
Net Charge0
Average Mass198.221
Monoisotopic Mass198.06808
SMILESO=C1CCc2c(ccc3ccccc23)O1
InChIInChI=1S/C13H10O2/c14-13-8-6-11-10-4-2-1-3-9(10)5-7-12(11)15-13/h1-5,7H,6,8H2
InChIKeyISFPDBUKMJDAJH-UHFFFAOYSA-N
Roles Classification
Biological Role:
Sir2 inhibitor  An EC 3.5.1.98 (histone deacetylase) inhibitor that interferes with the action of Sir2.
Application:
platelet aggregation inhibitor  A drug or agent which antagonizes or impairs any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
ChEBI Ontology
Outgoing Relation(s)
splitomicin (CHEBI:75272) has role platelet aggregation inhibitor (CHEBI:50427)
splitomicin (CHEBI:75272) has role Sir2 inhibitor (CHEBI:71181)
splitomicin (CHEBI:75272) is a benzochromenone (CHEBI:64986)
splitomicin (CHEBI:75272) is a naphtho-α-pyrone (CHEBI:146280)
splitomicin (CHEBI:75272) is a δ-lactone (CHEBI:18946)
IUPAC Name 
1,2-dihydro-3H-benzo[f]chromen-3-one
Synonym  Source
1,2-dihydro-3H-naphtho[2,1-b]-pyran-3-oneChEBI
Manual XrefsDatabases
KR20120128451Patent
LSM-2607LINCS
Registry NumbersSources
Reaxys:161649Reaxys
Citations