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CHEBI:748220 - cyclosporine
| Formula | C62H111N11O12 |
| Net Charge | 0 |
| Average Mass | 1202.635 |
| Monoisotopic Mass | 1201.84137 |
| SMILES | [H][C@]1([C@H](O)[C@H](C)C/C=C/C)C(=O)N[C@@H](CC)C(=O)N(C)CC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C |
| InChI | InChI=1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1 |
| InChIKey | PMATZTZNYRCHOR-CGLBZJNRSA-N |
| Roles Classification |
|---|
| Chemical Role: | Bronsted base A molecular entity capable of accepting a hydron from a donor (Brønsted acid). |
| Biological Roles: | anti-HIV agent An antiviral agent that destroys or inhibits the replication of the human immunodeficiency virus. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. leprostatic drug A substance that suppresses Mycobacterium leprae, ameliorates the clinical manifestations of leprosy, and/or reduces the incidence and severity of leprous reactions. antiviral agent A substance that destroys or inhibits replication of viruses. antibacterial agent A substance (or active part thereof) that kills or slows the growth of bacteria. antifungal agent An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce. |
| Applications: | hypoglycemic agent A drug which lowers the blood glucose level. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. renoprotective agent Any compound that is able to prevent damage to the kidneys. antiinfective agent A substance used in the prophylaxis or therapy of infectious diseases. antipsoriatic A drug used to treat psoriasis. antirheumatic drug A drug used to treat rheumatoid arthritis. leprostatic drug A substance that suppresses Mycobacterium leprae, ameliorates the clinical manifestations of leprosy, and/or reduces the incidence and severity of leprous reactions. neuroprotective agent Any compound that can be used for the treatment of neurodegenerative disorders. anti-anaemic agent A compound which increases either the number of red cells or the amount of haemoglobin in the blood. antiglaucoma drug Any drug which can be used to prevent or alleviate glaucoma, a disease in which the optic nerve is damaged, resulting in progressive, irreversible loss of vision. It is often, though not always, associated with increased pressure of the fluid in the eye. nephroprotective agent Any protective agent that is able to prevent damage to the kidney. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. cardiovascular drug A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume. anti-inflammatory agent Any compound that has anti-inflammatory effects. dermatologic drug A drug used to treat or prevent skin disorders or for the routine care of skin. ophthalmology drug Any compound used for the treatment of eye conditions or eye diseases. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| cyclosporine (CHEBI:748220) has role anti-anaemic agent (CHEBI:75835) |
| cyclosporine (CHEBI:748220) has role anti-HIV agent (CHEBI:64946) |
| cyclosporine (CHEBI:748220) has role anti-inflammatory agent (CHEBI:67079) |
| cyclosporine (CHEBI:748220) has role antibacterial agent (CHEBI:33282) |
| cyclosporine (CHEBI:748220) has role antifungal agent (CHEBI:35718) |
| cyclosporine (CHEBI:748220) has role antiglaucoma drug (CHEBI:39456) |
| cyclosporine (CHEBI:748220) has role antiinfective agent (CHEBI:35441) |
| cyclosporine (CHEBI:748220) has role antineoplastic agent (CHEBI:35610) |
| cyclosporine (CHEBI:748220) has role antipsoriatic (CHEBI:50748) |
| cyclosporine (CHEBI:748220) has role antirheumatic drug (CHEBI:35842) |
| cyclosporine (CHEBI:748220) has role antiviral agent (CHEBI:22587) |
| cyclosporine (CHEBI:748220) has role cardiovascular drug (CHEBI:35554) |
| cyclosporine (CHEBI:748220) has role dermatologic drug (CHEBI:50177) |
| cyclosporine (CHEBI:748220) has role hypoglycemic agent (CHEBI:35526) |
| cyclosporine (CHEBI:748220) has role immunosuppressive agent (CHEBI:35705) |
| cyclosporine (CHEBI:748220) has role leprostatic drug (CHEBI:35816) |
| cyclosporine (CHEBI:748220) has role nephroprotective agent (CHEBI:76595) |
| cyclosporine (CHEBI:748220) has role neuroprotective agent (CHEBI:63726) |
| cyclosporine (CHEBI:748220) has role ophthalmology drug (CHEBI:66981) |
| cyclosporine (CHEBI:748220) has role renoprotective agent (CHEBI:231911) |
| cyclosporine (CHEBI:748220) is a homodetic cyclic peptide (CHEBI:24613) |
| Synonyms | Source |
|---|---|
| 27-400 | ChEMBL |
| ANTIBIOTIC S-7481F1 | ChEMBL |
| Atopica | ChEMBL |
| Ciclosporin a | ChEMBL |
| Cyclosporine a | ChEMBL |
| Cyclosporine microemulsion | ChEMBL |
| Brand Names | Source |
|---|---|
| Capimune | ChEMBL |
| Capsorin | ChEMBL |
| Cequa | ChEMBL |
| Deximune | ChEMBL |
| Ikervis | ChEMBL |
| Optimmune | ChEMBL |
| Citations |
|---|