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CHEBI:747872 - BRD0705

Default Structure
ChEBI IDCHEBI:747872
ChEBI NameBRD0705
Stars
DefinitionBRD0705 is a potent, paralog selective and orally active GSK3α inhibitor with an IC50 of 66 nM and a Kd of 4.8 μM. BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC50 of 515 nM). BRD0705 can be used for acute myeloid leukemia (AML) research.
Last Modified9 June 2026
Submittercyan
DownloadsMolfile
FormulaC20H23N3O
Net Charge0
Average Mass321.424
Monoisotopic Mass321.18411
SMILESCC[C@]1(c2ccccc2)C2=CNNC2=NC2=C1C(=O)CC(C)(C)C2
InChIInChI=1S/C20H23N3O/c1-4-20(13-8-6-5-7-9-13)14-12-21-23-18(14)22-15-10-19(2,3)11-16(24)17(15)20/h5-9,12H,4,10-11H2,1-3H3,(H2,21,22,23)/t20-/m0/s1
InChIKeyNCKLQXXBRWCYMA-FQEVSTJZSA-N
ChEBI Ontology
Outgoing Relation(s)
BRD0705 (CHEBI:747872) is a organic molecular entity (CHEBI:50860)
Registry NumbersSources
CAS:2056261-41-5CAS