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CHEBI:747849 - NPD2560

Default Structure
ChEBI IDCHEBI:747849
ChEBI NameNPD2560
Stars
DefinitionAn organic heterotricyclic compound that is 9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one substituted by 4-methoxyphenyl and 2,4-difluorophenyl groups at positions 4 and 9, respectively. It is an antifungal agent that exhibits fungicidal activity against Candida krusei. Its mechanism of action involves the disruption of the Rho1-Fks1 signaling pathway which is essential in cell wall construction.
Last Modified29 June 2026
Submitterrnash
DownloadsMolfile
FormulaC24H17F2NO4
Net Charge0
Average Mass421.399
Monoisotopic Mass421.11256
SMILESCOc1ccc(-c2cc(=O)oc3c4c(ccc23)OCN(c2ccc(F)cc2F)C4)cc1
InChIInChI=1S/C24H17F2NO4/c1-29-16-5-2-14(3-6-16)18-11-23(28)31-24-17(18)7-9-22-19(24)12-27(13-30-22)21-8-4-15(25)10-20(21)26/h2-11H,12-13H2,1H3
InChIKeyJXSCUIVTIWDPBB-UHFFFAOYSA-N
Roles Classification
Biological Role:
antifungal agent  An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce.
ChEBI Ontology
Outgoing Relation(s)
NPD2560 (CHEBI:747849) has role antifungal agent (CHEBI:35718)
NPD2560 (CHEBI:747849) is a difluorobenzene (CHEBI:38582)
NPD2560 (CHEBI:747849) is a monomethoxybenzene (CHEBI:25235)
NPD2560 (CHEBI:747849) is a organic heterotricyclic compound (CHEBI:26979)
IUPAC Name 
9-(2,4-difluorophenyl)-4-(4-methoxyphenyl)-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one
Synonyms  Source
9-(2,4-difluorophenyl)-4-(4-methoxyphenyl)-2H,8H,9H,10H-chromeno[8,7-e][1,3]oxazin-2-oneChEBI
9-(2,4-difluorophenyl)-4-(4-methoxyphenyl)-9,10-dihydro-2H,8H-pyrano[2,3-f][1,3]benzoxazin-2-oneIUPAC
NPD 2560ChEBI
NPD-2560ChEBI
Citations