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CHEBI:747804 - Pf-03814735

Default Structure
ChEBI IDCHEBI:747804
ChEBI NamePf-03814735
Stars
DefinitionAn aurora kinase inhibitor with potential antineoplastic activity. PF-03814735 binds to and inhibits aurora kinases, serine-threonine kinases that play essential roles in mitotic checkpoint control during mitosis. Inhibition of aurora kinases may result in an inhibition of cellular division and proliferation in tumor cells that overexpress aurora kinases.
Last Modified27 May 2026
Submitterjychien
DownloadsMolfile
FormulaC23H25F3N6O2
Net Charge0
Average Mass474.487
Monoisotopic Mass474.19911
SMILES[H]c1nc(N([H])c2c([H])c([H])c3c(c2[H])[C@]2([H])N(C(=O)C([H])([H])N([H])C(=O)C([H])([H])[H])[C@@]3([H])C([H])([H])C2([H])[H])nc(N([H])C2([H])C([H])([H])C([H])([H])C2([H])[H])c1C(F)(F)F
InChIInChI=1S/C23H25F3N6O2/c1-12(33)27-11-20(34)32-18-7-8-19(32)16-9-14(5-6-15(16)18)30-22-28-10-17(23(24,25)26)21(31-22)29-13-3-2-4-13/h5-6,9-10,13,18-19H,2-4,7-8,11H2,1H3,(H,27,33)(H2,28,29,30,31)/t18-,19+/m0/s1
InChIKeyRYYNGWLOYLRZLK-RBUKOAKNSA-N
ChEBI Ontology
Outgoing Relation(s)
Pf-03814735 (CHEBI:747804) is a organic molecular entity (CHEBI:50860)
IUPAC Name 
N-[2-[(1R,8S)-4-[[4-(cyclobutylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-11-azatricyclo[6.2.1.02,7]undeca-2(7),3,5-trien-11-yl]-2-oxoethyl]acetamide
Synonyms  Source
PF 03814735PubChem Compound
PF-03814735PubChem Compound
PF 3814735PubChem Compound
PF-3814735PubChem Compound
Registry NumbersSources
CAS:942487-16-3CAS