EMBL-EBI | Chemical Biology | ChEBI

Example searches: iron*, InChI=1S/CH4O/c1-2/h2H,1H3, caffeine | Advanced Search

CHEBI:747721 - AMG 900

Default Structure
ChEBI IDCHEBI:747721
ChEBI NameAMG 900
Stars
DefinitionAMG 900 is a small-molecule inhibitor of Aurora kinases A, B and C with potential antineoplastic activity. Aurora kinase inhibitor AMG 900 selectively binds to and inhibits the activities of Aurora kinases A, B and C, which may result in inhibition of cellular division and proliferation in tumor cells that overexpress these kinases.
Last Modified29 May 2026
Submitterjychien
DownloadsMolfile
FormulaC28H21N7OS
Net Charge0
Average Mass503.591
Monoisotopic Mass503.15283
SMILES[H]c1nc(N([H])[H])nc(-c2c(Oc3c([H])c([H])c(N([H])c4nnc(-c5sc([H])c(C([H])([H])[H])c5[H])c5c([H])c([H])c([H])c([H])c45)c([H])c3[H])nc([H])c([H])c2[H])c1[H]
InChIInChI=1S/C28H21N7OS/c1-17-15-24(37-16-17)25-20-5-2-3-6-21(20)26(35-34-25)32-18-8-10-19(11-9-18)36-27-22(7-4-13-30-27)23-12-14-31-28(29)33-23/h2-16H,1H3,(H,32,35)(H2,29,31,33)
InChIKeyIVUGFMLRJOCGAS-UHFFFAOYSA-N
ChEBI Ontology
Outgoing Relation(s)
AMG 900 (CHEBI:747721) is a organic molecular entity (CHEBI:50860)
IUPAC Name 
N-[4-[[3-(2-aminopyrimidin-4-yl)-2-pyridinyl]oxy]phenyl]-4-(4-methylthiophen-2-yl)phthalazin-1-amine
Synonyms  Source
AMG-900ChEMBL
AMG900ChEMBL
N-(4-((3-(2-Amino-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-4-(4-methyl-2-thienyl)-1-phthalazinaminePubChem Compound
Registry NumbersSources
CAS:945595-80-2CAS
Citations