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CHEBI:747473 - vepdegestrant

Default Structure
ChEBI IDCHEBI:747473
ChEBI Namevepdegestrant
Stars
DefinitionAn oral proteolysis-targeting chimera (PROTAC) estrogen receptor (ER) degrader designed to target ER-driven breast cancer, currently under clinical evaluation.
Last Modified26 March 2026
SubmitterAnneNiknejad
DownloadsMolfile
FormulaC45H49N5O4
Net Charge0
Average Mass723.918
Monoisotopic Mass723.37846
SMILES[H][C@@]1(c2ccc(N3CCC(CN4CCN(c5ccc6c(c5)CN([C@@]5([H])CCC(=O)NC5=O)C6=O)CC4)CC3)cc2)c2ccc(O)cc2CC[C@]1([H])c1ccccc1
InChIInChI=1S/C45H49N5O4/c51-37-12-15-39-33(27-37)8-13-38(31-4-2-1-3-5-31)43(39)32-6-9-35(10-7-32)48-20-18-30(19-21-48)28-47-22-24-49(25-23-47)36-11-14-40-34(26-36)29-50(45(40)54)41-16-17-42(52)46-44(41)53/h1-7,9-12,14-15,26-27,30,38,41,43,51H,8,13,16-25,28-29H2,(H,46,52,53)/t38-,41+,43+/m1/s1
InChIKeyTZZDVPMABRWKIZ-XMOGEVODSA-N
ChEBI Ontology
Outgoing Relation(s)
vepdegestrant (CHEBI:747473) is a organic molecular entity (CHEBI:50860)
Manual XrefsDatabases
D12628KEGG DRUG
DB19006DrugBank
Registry NumbersSources
CAS:2229711-68-4DrugBank