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CHEBI:747375 - 2BAct

Default Structure
ChEBI IDCHEBI:747375
ChEBI Name2BAct
Stars
Definition2BAct is a highly selective, and orally active eIF2B (eukaryotic initiation factor 2B) activator with an EC50 of 33 nM. 2BAct prevents neurological defects caused by a chronic integrated stress response. 2BAct is able to penetrate the central nervous system (CNS). 2BAct displays improved solubility and pharmacokinetics relative to eIF2B activator ISRIB trans-isomer (HY-12495).
Last Modified19 February 2026
Submittercyan
DownloadsMolfile
FormulaC19H16ClF3N4O3
Net Charge0
Average Mass440.809
Monoisotopic Mass440.08630
SMILESO=C(COc1ccc(Cl)c(F)c1)NC12CC(NC(=O)c3cnc(C(F)F)cn3)(C1)C2
InChIInChI=1S/C19H16ClF3N4O3/c20-11-2-1-10(3-12(11)21)30-6-15(28)26-18-7-19(8-18,9-18)27-17(29)14-5-24-13(4-25-14)16(22)23/h1-5,16H,6-9H2,(H,26,28)(H,27,29)
InChIKeyHYQJXXCYOYRNMP-UHFFFAOYSA-N
ChEBI Ontology
Outgoing Relation(s)
2BAct (CHEBI:747375) is a organic molecular entity (CHEBI:50860)
Registry NumbersSources
CAS:2143542-28-1CAS