Naporafenib (CHEBI:747299)

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CHEBI:747299 - Naporafenib

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ChEBI ID	CHEBI:747299
ChEBI Name	Naporafenib
Stars
Definition	Naporafenib (LXH254) is a potent, selective, orally active, type II BRAF and CRAF inhibitor, with IC50 values of 0.072 and 0.21 nM against CRAF and BRAF, respectively.
Last Modified	2 February 2026
Submitter	cyan
Downloads	Molfile

Formula	C25H25F3N4O4
Net Charge	0
Average Mass	502.493
Monoisotopic Mass	502.18279
SMILES	Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1cc(OCCO)nc(N2CCOCC2)c1
InChI	InChI=1S/C25H25F3N4O4/c1-16-2-3-19(30-24(34)17-4-5-29-21(12-17)25(26,27)28)15-20(16)18-13-22(32-6-9-35-10-7-32)31-23(14-18)36-11-8-33/h2-5,12-15,33H,6-11H2,1H3,(H,30,34)
InChIKey	UEPXBTCUIIGYCY-UHFFFAOYSA-N

Roles Classification

antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms.

ChEBI Ontology

Outgoing Relation(s)
	Naporafenib (CHEBI:747299) has role antineoplastic agent (CHEBI:35610)
	Naporafenib (CHEBI:747299) is a organic molecular entity (CHEBI:50860)

INN	Source
naporafenib	WHO MedNet

Synonyms	Source
ERAS-254	ChEMBL
Lxh 254	ChEMBL
LXH-254	ChEMBL
LXH254	PubChem Compound
PAN-RAF INHIBITOR LXH254	ChEMBL

Registry Numbers	Sources
CAS:1800398-38-2	CAS

Citations