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CHEBI:747299 - Naporafenib

Default Structure
ChEBI IDCHEBI:747299
ChEBI NameNaporafenib
Stars
DefinitionNaporafenib (LXH254) is a potent, selective, orally active, type II BRAF and CRAF inhibitor, with IC50 values of 0.072 and 0.21 nM against CRAF and BRAF, respectively.
Last Modified2 February 2026
Submittercyan
DownloadsMolfile
FormulaC25H25F3N4O4
Net Charge0
Average Mass502.493
Monoisotopic Mass502.18279
SMILESCc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1cc(OCCO)nc(N2CCOCC2)c1
InChIInChI=1S/C25H25F3N4O4/c1-16-2-3-19(30-24(34)17-4-5-29-21(12-17)25(26,27)28)15-20(16)18-13-22(32-6-9-35-10-7-32)31-23(14-18)36-11-8-33/h2-5,12-15,33H,6-11H2,1H3,(H,30,34)
InChIKeyUEPXBTCUIIGYCY-UHFFFAOYSA-N
ChEBI Ontology
Outgoing Relation(s)
Naporafenib (CHEBI:747299) is a organic molecular entity (CHEBI:50860)
Synonym  Source
LXH254PubChem Compound
Registry NumbersSources
CAS:1800398-38-2CAS