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CHEBI:747123 - zoliflodacin

Default Structure
ChEBI IDCHEBI:747123
ChEBI Namezoliflodacin
Stars
DefinitionA first-in-class spiropyrimidinetrione antibiotic acting as topoisomerase II inhibitor and indicated for the treatment of uncomplicated urogenital gonorrhea caused by Neisseria gonorrhoeae.
Last Modified7 January 2026
SubmitterAnneNiknejad
DownloadsMolfile
FormulaC22H22FN5O7
Net Charge0
Average Mass487.444
Monoisotopic Mass487.15033
SMILES[H][C@]12[C@H](C)O[C@H](C)CN1c1c(cc3c(N4C(=O)OC[C@@H]4C)noc3c1F)CC21C(=O)NC(=O)NC1=O
InChIInChI=1S/C22H22FN5O7/c1-8-7-33-21(32)28(8)17-12-4-11-5-22(18(29)24-20(31)25-19(22)30)16-10(3)34-9(2)6-27(16)14(11)13(23)15(12)35-26-17/h4,8-10,16H,5-7H2,1-3H3,(H2,24,25,29,30,31)/t8-,9+,10-,16+/m0/s1
InChIKeyZSWMIFNWDQEXDT-ZESJGQACSA-N
Roles Classification
Biological Role:
topoisomerase II inhibitor  A topoisomerase inhibitor that inhibits DNA topoisomerase II.
ChEBI Ontology
Outgoing Relation(s)
zoliflodacin (CHEBI:747123) has role topoisomerase II inhibitor (CHEBI:156203)
Synonyms  Source
AZD 0914CAS
AZD-0914CAS
AZD0914CAS
ETX 0914CAS
Brand Name  Source
NuzolvenceKEGG DRUG
Manual XrefsDatabases
D11726KEGG DRUG
DB12817DrugBank
Registry NumbersSources
CAS:1620458-09-4CAS