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CHEBI:746980 - A-366
| ChEBI ID | CHEBI:746980 |
| ChEBI Name | A-366 |
| Stars | |
| Definition | A-366, a chemical probe, is a potent, highly selective, peptide-competitive histone methyltransferase G9a inhibitor with IC50s of 3.3 and 38 nM for G9a and GLP (EHMT1), respectively. A-366 shows >1000-fold selectivity over 21 other methyltransferases. A-366 is also a potent, nanomolar inhibitor of the Spindlin1-H3K4me3-interaction (IC50=182.6 nM). A-366 displays high affinity at human histamine H3 receptor (Ki=17 nM) and shows subtype selectivity among subsets of the histaminergic and dopaminergic receptor families. |
| Last Modified | 24 November 2025 |
| Submitter | cyan |
| Formula | C19H27N3O2 |
| Net Charge | 0 |
| Average Mass | 329.444 |
| Monoisotopic Mass | 329.21033 |
| ChEBI Ontology |
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| Outgoing Relation(s) |
| A-366 (CHEBI:746980) is a organic molecular entity (CHEBI:50860) |
| Registry Numbers | Sources |
|---|---|
| CAS:1527503-11-2 | PubChem Compound |