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CHEBI:746976 - Sotuletinib

ChEBI IDCHEBI:746976
ChEBI NameSotuletinib
Stars
DefinitionSotuletinib is an inhibitor of colony stimulating factor 1 receptor (CSF-1R; CSF1R), with potential antineoplastic activity. It selectively binds to CSF1R expressed on tumor-associated macrophages (TAMs), blocks the activity of CSF1R, and inhibits CSF1R-mediated signal transduction pathways. This inhibits the activity and proliferation of TAMs, and reprograms the immunosuppressive nature of existing TAMs. Altogether, this reduces TAM-mediated immune suppression in the tumor microenvironment, re-activates the immune system, and improves anti-tumor cell responses mediated by T-cells.
Last Modified24 November 2025
Submittercyan
FormulaC20H22N4O3S
Net Charge0
Average Mass398.488
Monoisotopic Mass398.14126
ChEBI Ontology
Outgoing Relation(s)
Sotuletinib (CHEBI:746976) is a organic molecular entity (CHEBI:50860)
Synonyms  Source
blz945PubChem Compound
BLZ-945PubChem Compound
Registry NumbersSources
CAS:953769-46-5PubChem Compound