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CHEBI:746969 - Roflumilast N-oxide (RNO)

ChEBI IDCHEBI:746969
ChEBI NameRoflumilast N-oxide (RNO)
Stars
DefinitionRoflumilast N-oxide is an inhibitor of phosphodiesterase 4 (PDE4; IC50 = 2 nM) and an active metabolite of the PDE4 inhibitor roflumilast (Item No. 15141).1 It is selective for PDE4 over PDE1-3 and PDE5.
Last Modified24 November 2025
Submittercyan
FormulaC17H14Cl2F2N2O4
Net Charge0
Average Mass419.211
Monoisotopic Mass418.02987
ChEBI Ontology
Outgoing Relation(s)
Roflumilast N-oxide (RNO) (CHEBI:746969) is a organic molecular entity (CHEBI:50860)
IUPAC Name 
3-(Cyclopropylmethoxy)-N-(3,5-dichloro-1-oxido-4-pyridinyl)-4-(difluoromethoxy)benzamide
Synonym  Source
BYK22890PubChem Compound
Registry NumbersSources
CAS:292135-78-5PubChem Compound