EMBL-EBI | Chemical Biology | ChEBI

Example searches: iron*, InChI=1S/CH4O/c1-2/h2H,1H3, caffeine | Advanced Search

CHEBI:746968 - TEPP-46

Default Structure
ChEBI IDCHEBI:746968
ChEBI NameTEPP-46
Stars
DefinitionTEPP-46 is a potent and selective pyruvate kinase M2 (PKM2) activator with an AC50 of 92 nM, showing little or no effect on PKM1, PKL and PKR.
Last Modified20 April 2026
Submittercyan
DownloadsMolfile
FormulaC17H16N4O2S2
Net Charge0
Average Mass372.475
Monoisotopic Mass372.07147
SMILESCn1c2cc(S(C)=O)sc2c2cnn(Cc3cccc(N)c3)c(=O)c21
InChIInChI=1S/C17H16N4O2S2/c1-20-13-7-14(25(2)23)24-16(13)12-8-19-21(17(22)15(12)20)9-10-4-3-5-11(18)6-10/h3-8H,9,18H2,1-2H3
InChIKeyZWKJWVSEDISQIS-UHFFFAOYSA-N
Roles Classification
Chemical Role:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
ChEBI Ontology
Outgoing Relation(s)
TEPP-46 (CHEBI:746968) is a organic heterotricyclic compound (CHEBI:26979)
TEPP-46 (CHEBI:746968) is a substituted aniline (CHEBI:48975)
TEPP-46 (CHEBI:746968) is a sulfone (CHEBI:35850)
IUPAC Name 
6-(3-aminobenzyl)-4-methyl-2-(methylsulfinyl)-4,6-dihydro-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one
Synonym  Source
ML265IUPHAR
Registry NumbersSources
CAS:1221186-53-3CAS