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CHEBI:746918 - Bravizine: N-[4-[(4-hydroxy-3-tert-butylphenyl)methyl]-1-piperazinyl]benzamide

Default Structure
ChEBI IDCHEBI:746918
ChEBI NameBravizine: N-[4-[(4-hydroxy-3-tert-butylphenyl)methyl]-1-piperazinyl]benzamide
Stars
DefinitionA synthetic small-molecule compound designed as a β-arrestin–biased partial agonist of the dopamine D2 receptor. Structurally, it is a substituted benzamide containing a piperazinyl linkage and a tert-butylphenol moiety. Bravizine was developed through AI-augmented ligand optimization to selectively modulate D2R signaling by favoring β-arrestin recruitment over G-protein activation, with potential therapeutic application in the treatment of tardive dyskinesia.
Last Modified5 November 2025
SubmitterAaryan Senthilvanan
DownloadsMolfile
FormulaC23H31N3O2
Net Charge0
Average Mass381.520
Monoisotopic Mass381.24163
SMILESCNC(=O)c1ccc(N2CCN(Cc3cc(C(C)(C)C)ccc3O)CC2)cc1
InChIInChI=1S/C23H31N3O2/c1-23(2,3)19-7-10-21(27)18(15-19)16-25-11-13-26(14-12-25)20-8-5-17(6-9-20)22(28)24-4/h5-10,15,27H,11-14,16H2,1-4H3,(H,24,28)
InChIKeyRBYUZYLLGIQLMA-UHFFFAOYSA-N
ChEBI Ontology
Outgoing Relation(s)
Bravizine: N-[4-[(4-hydroxy-3-tert-butylphenyl)methyl]-1-piperazinyl]benzamide (CHEBI:746918) is a organic molecular entity (CHEBI:50860)
Brand Name  Source
BravizinePatent