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CHEBI:74498 - 5-fluoroorotic acid
| ChEBI ID | CHEBI:74498 |
| ChEBI Name | 5-fluoroorotic acid |
| Stars | |
| Definition | A pyrimidinemonocarboxylic that is orotic acid which is substituted by fluorine at position 5. It is used in yeast molecular genetics to detect expression of the URA3 gene, which encodes orotine-5'-monophosphate dicarboxylase. A yeast with and active URA3 gene converts 5-fluoroorotic acid to fluorodeoxyuridine, which is toxic to cells. |
| Last Modified | 3 July 2013 |
| Submitter | Gareth Owen |
| Roles Classification |
|---|
| Chemical Role: | Bronsted acid A molecular entity capable of donating a hydron to an acceptor (Brønsted base). |
| ChEBI Ontology |
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| Outgoing Relation(s) |
| 5-fluoroorotic acid (CHEBI:74498) is a nucleobase analogue (CHEBI:67142) |
| 5-fluoroorotic acid (CHEBI:74498) is a organofluorine compound (CHEBI:37143) |
| 5-fluoroorotic acid (CHEBI:74498) is a pyrimidinemonocarboxylic acid (CHEBI:26447) |
| IUPAC Name |
|---|
| 5-fluoro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid |
| Synonyms | Source |
|---|---|
| FOA | ChemIDplus |
| ENT-26398 | ChemIDplus |
| NSC-31712 | ChEBI |
| 1,2,3,6-tetrahydro-2,6-dioxo-5-fluoro-4-pyrimidinecarboxylic acid | ChemIDplus |
| 5-fluoro-1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinecarboxylic acid | ChEBI |
| 5-fluoro-6-carboxyuracil | ChEBI |
| Citations |
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