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CHEBI:73410 - nisoxetine

ChEBI IDCHEBI:73410
ChEBI Namenisoxetine
Stars
DefinitionA secondary amino compound that is N-methyl-3-phenylpropan-1-amine substituted at position 3 by a 2-methoxyphenoxy group.
Last Modified5 March 2020
SubmitterMargaret Duesbury
DownloadsMolfile
FormulaC17H21NO2
Net Charge0
Average Mass271.360
Monoisotopic Mass271.15723
SMILESCNCCC(Oc1ccccc1OC)c1ccccc1
InChIInChI=1S/C17H21NO2/c1-18-13-12-15(14-8-4-3-5-9-14)20-17-11-7-6-10-16(17)19-2/h3-11,15,18H,12-13H2,1-2H3
InChIKeyITJNARMNRKSWTA-UHFFFAOYSA-N
Wikipedia
Roles Classification
Chemical Role:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Role:
adrenergic uptake inhibitor  Adrenergic uptake inhibitors are drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin.
Applications:
adrenergic uptake inhibitor  Adrenergic uptake inhibitors are drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin.
antidepressant  Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions.
ChEBI Ontology
Outgoing Relation(s)
nisoxetine (CHEBI:73410) has role adrenergic uptake inhibitor (CHEBI:35640)
nisoxetine (CHEBI:73410) has role antidepressant (CHEBI:35469)
nisoxetine (CHEBI:73410) is a aromatic ether (CHEBI:35618)
nisoxetine (CHEBI:73410) is a secondary amino compound (CHEBI:50995)
Incoming Relation(s)
nisoxetine hydrochloride (CHEBI:232874) has part nisoxetine (CHEBI:73410)
IUPAC Name 
3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-amine
INNs  Source
nisoxetineKEGG DRUG
nisoxétineWHO MedNet
nisoxetinumWHO MedNet
nisoxetinaWHO MedNet
Synonyms  Source
3-(2-Methoxyphenoxy)-N-methyl-3-phenylpropylamineChemIDplus
3-(o-Methoxyphenoxy)-N-methyl-3-phenylpropylamineChemIDplus
N-Methyl-gamma-(2-methylphenoxy)phenylpropanolamineChemIDplus
DL-N-Methyl-3-(o-methoxyphenoxy)-N-methyl-3-phenylpropylamineChemIDplus
Manual XrefsDatabases
D05173KEGG DRUG
NisoxetineWikipedia
LSM-1934LINCS
Registry NumbersSources
Reaxys:2946689Reaxys
CAS:53179-07-0KEGG DRUG
CAS:53179-07-0ChemIDplus
CAS:57226-61-6ChemIDplus
Citations