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CHEBI:71955 - GSK1059615

ChEBI IDCHEBI:71955
ChEBI NameGSK1059615
Stars
DefinitionA thiazolidinone that is the 5-{[4-(pyridin-4-yl)quinolin-6-yl]methylene} derivative of 1,3-thiazolidine-2,4-dione. A PI3K inhibitor
Last Modified6 July 2016
SubmitterBijay
DownloadsMolfile
FormulaC18H11N3O2S
Net Charge0
Average Mass333.372
Monoisotopic Mass333.05720
SMILES[H]C(=C1SC(=O)NC1=O)c1ccc2nccc(-c3ccncc3)c2c1
InChIInChI=1S/C18H11N3O2S/c22-17-16(24-18(23)21-17)10-11-1-2-15-14(9-11)13(5-8-20-15)12-3-6-19-7-4-12/h1-10H,(H,21,22,23)
InChIKeyQDITZBLZQQZVEE-UHFFFAOYSA-N
Roles Classification
Biological Role:
EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor  An inhibitor of phosphatidylinositol 3-kinase, EC 2.7.1.137, a family of related enzymes capable of phosphorylating the 3 position hydroxy group of the inositol ring of a phosphatidylinositol.
Application:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
GSK1059615 (CHEBI:71955) has role antineoplastic agent (CHEBI:35610)
GSK1059615 (CHEBI:71955) has role EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor (CHEBI:50914)
GSK1059615 (CHEBI:71955) is a pyridines (CHEBI:26421)
GSK1059615 (CHEBI:71955) is a quinolines (CHEBI:26513)
GSK1059615 (CHEBI:71955) is a thiazolidinone (CHEBI:48891)
Synonym  Source
5-{[4-(pyridin-4-yl)quinolin-6-yl]methylene}-1,3-thiazolidine-2,4-dioneChEBI
Manual XrefsDatabases
LSM-1173LINCS
Registry NumbersSources
Reaxys:20875363Reaxys