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CHEBI:71013 - perampanel

ChEBI IDCHEBI:71013
ChEBI Nameperampanel
Stars
DefinitionA member of the class of bipyridines that is 2,3'-bipyridin-6'-one substituted at positions 1' and 5' by phenyl and 2-cyanophenyl groups respectively. Used as an adjunctive therapy for the treatment of partial-onset seizures in patients with epilepsy.
Last Modified22 February 2017
SubmitterSteve
DownloadsMolfile
FormulaC23H15N3O
Net Charge0
Average Mass349.393
Monoisotopic Mass349.12151
SMILESN#Cc1ccccc1-c1cc(-c2ccccn2)cn(-c2ccccc2)c1=O
InChIInChI=1S/C23H15N3O/c24-15-17-8-4-5-11-20(17)21-14-18(22-12-6-7-13-25-22)16-26(23(21)27)19-9-2-1-3-10-19/h1-14,16H
InChIKeyPRMWGUBFXWROHD-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Role:
AMPA receptor antagonist  An antagonist at the AMPA receptor.
Application:
anticonvulsant  A drug used to prevent seizures or reduce their severity.
ChEBI Ontology
Outgoing Relation(s)
perampanel (CHEBI:71013) has functional parent benzonitrile (CHEBI:27991)
perampanel (CHEBI:71013) has role AMPA receptor antagonist (CHEBI:71014)
perampanel (CHEBI:71013) has role anticonvulsant (CHEBI:35623)
perampanel (CHEBI:71013) is a bipyridines (CHEBI:50511)
perampanel (CHEBI:71013) is a nitrile (CHEBI:18379)
perampanel (CHEBI:71013) is a pyridone (CHEBI:38183)
Incoming Relation(s)
perampanel hydrate (CHEBI:71015) has part perampanel (CHEBI:71013)
IUPAC Name 
2-(6'-oxo-1'-phenyl-1',6'-dihydro-2,3'-bipyridin-5'-yl)benzonitrile
INNs  Source
pérampanelWHO MedNet
perampanelWHO MedNet
perampanelWHO MedNet
perampanelumWHO MedNet
Synonyms  Source
3-(2-Cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-oneChemIDplus
E 2007ChemIDplus
ER-155055-90ChemIDplus
E2007ChemIDplus
Brand Name  Source
FycompaKEGG DRUG
Manual XrefsDatabases
D08964KEGG DRUG
PerampanelWikipedia
US2009088574Patent
US2008108603Patent
WO2008111590Patent
WO2006107859Patent
EP1875912Patent
4684DrugCentral
Registry NumbersSources
Reaxys:11343244Reaxys
CAS:380917-97-5KEGG DRUG
CAS:380917-97-5ChemIDplus
Citations