CHEBI:6950 - mirtazapine

ChEBI IDCHEBI:6950
ChEBI Namemirtazapine
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Last Modified8 July 2021
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FormulaC17H19N3
Net Charge0
Average Mass265.360
Monoisotopic Mass265.15790
SMILESCN1CCN2c3ncccc3Cc3ccccc3C2C1
InChIInChI=1S/C17H19N3/c1-19-9-10-20-16(12-19)15-7-3-2-5-13(15)11-14-6-4-8-18-17(14)20/h2-8,16H,9-12H2,1H3
InChIKeyRONZAEMNMFQXRA-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Roles:
alpha-adrenergic antagonist  An agent that binds to but does not activate α-adrenergic receptors thereby blocking the actions of endogenous or exogenous α-adrenergic agonists. α-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
H1-receptor antagonist  H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
serotonergic antagonist  Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
histamine antagonist  Histamine antagonists are the drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists.
Applications:
anxiolytic drug  Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions.
alpha-adrenergic antagonist  An agent that binds to but does not activate α-adrenergic receptors thereby blocking the actions of endogenous or exogenous α-adrenergic agonists. α-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
oneirogen  Any substance that produces or enhances dream-like states of consciousness.
H1-receptor antagonist  H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
serotonergic antagonist  Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
histamine antagonist  Histamine antagonists are the drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists.
antidepressant  Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions.
ChEBI Ontology
Outgoing Relation(s)
mirtazapine (CHEBI:6950) has role anxiolytic drug (CHEBI:35474)
mirtazapine (CHEBI:6950) has role H1-receptor antagonist (CHEBI:37955)
mirtazapine (CHEBI:6950) has role histamine antagonist (CHEBI:37956)
mirtazapine (CHEBI:6950) has role oneirogen (CHEBI:146270)
mirtazapine (CHEBI:6950) has role serotonergic antagonist (CHEBI:48279)
mirtazapine (CHEBI:6950) has role α-adrenergic antagonist (CHEBI:37890)
mirtazapine (CHEBI:6950) is a benzazepine (CHEBI:35676)
mirtazapine (CHEBI:6950) is a tetracyclic antidepressant (CHEBI:50940)
IUPAC Name 
2-methyl-1,2,3,4,10,14b-hexahydropyrazino[2,1-a]pyrido[2,3-c][2]benzazepine
INNs  Source
mirtazapineChEBI
mirtazapinaChEBI
mirtazapinumChEBI
Synonyms  Source
MirtazapineKEGG COMPOUND
1,2,3,4,10,14b-Hexahydro-2-methylpyrazino(2,1-a)pyrido(2,3-c)benzazepineChemIDplus
Manual XrefsDatabases
C07570KEGG COMPOUND
D00563KEGG DRUG
DE2614406Patent
US4062848Patent
DB00370DrugBank
MirtazapineWikipedia
LSM-1706LINCS
1816DrugCentral
2980VSDB
Registry NumbersSources
Beilstein:549345Beilstein
CAS:61337-67-5ChemIDplus
Citations