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CHEBI:691037 - desoximetasone

ChEBI IDCHEBI:691037
ChEBI Namedesoximetasone
Stars
DefinitionDexamethasone in which the hydroxy group at the 17α position is substituted by hydrogen. A synthetic corticosteroid with glucocorticoid activity, it is used as an anti-inflammatory and anti-pruritic in the treatment of various skin disorders, including skin allergies and psoriasis.
Last Modified6 February 2018
DownloadsMolfile
FormulaC22H29FO4
Net Charge0
Average Mass376.468
Monoisotopic Mass376.20499
SMILES[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1(F)[C@@H](O)C[C@]1(C)[C@@H](C(=O)CO)[C@H](C)C[C@@]21[H]
InChIInChI=1S/C22H29FO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-21(13,3)22(15,23)18(27)10-20(16,2)19(12)17(26)11-24/h6-7,9,12,15-16,18-19,24,27H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,18+,19-,20+,21+,22+/m1/s1
InChIKeyVWVSBHGCDBMOOT-IIEHVVJPSA-N
Wikipedia
Roles Classification
Biological Role:
hormone  Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds.
Applications:
antipruritic drug  A drug, usually applied topically, that relieves pruritus (itching).
anti-inflammatory drug  A substance that reduces or suppresses inflammation.
ChEBI Ontology
Outgoing Relation(s)
desoximetasone (CHEBI:691037) has role anti-inflammatory drug (CHEBI:35472)
desoximetasone (CHEBI:691037) has role antipruritic drug (CHEBI:59683)
desoximetasone (CHEBI:691037) is a 11β-hydroxy steroid (CHEBI:35346)
desoximetasone (CHEBI:691037) is a 20-oxo steroid (CHEBI:36885)
desoximetasone (CHEBI:691037) is a 21-hydroxy steroid (CHEBI:35344)
desoximetasone (CHEBI:691037) is a 3-oxo-Δ1,Δ4-steroid (CHEBI:77166)
desoximetasone (CHEBI:691037) is a fluorinated steroid (CHEBI:50830)
desoximetasone (CHEBI:691037) is a glucocorticoid (CHEBI:24261)
desoximetasone (CHEBI:691037) is a primary α-hydroxy ketone (CHEBI:139590)
IUPAC Name 
9-fluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione
INNs  Source
desoximetasonumChemIDplus
desoximetasoneChemIDplus
desoximetasonaChemIDplus
Synonyms  Source
(11β,16α)-9-fluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dioneChEBI
9α-fluoro-16α-methyl-Δ1-corticosteroneChEBI
desoxymethasoneChEBI
Manual XrefsDatabases
D03697KEGG DRUG
DB00547DrugBank
FR1296544Patent
US3099654Patent
BE314196Patent
US3232839Patent
DesoximetasoneWikipedia
819DrugCentral
Registry NumbersSources
Beilstein:2228097Beilstein
CAS:382-67-2ChemIDplus