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CHEBI:66634 - nocardione A

ChEBI IDCHEBI:66634
ChEBI Namenocardione A
Stars
DefinitionA naphthofuran that is 2,3-dihydronaphtho[1,2-b]furan-4,5-dione substitutd by a hydroxy group at position 6 and a methyl group at position 2. It is isolated from Norcardia sp.TC-A0248 and acts as a protein tyrosine phosphatase inhibitor.
Last Modified6 June 2016
DownloadsMolfile
FormulaC13H10O4
Net Charge0
Average Mass230.219
Monoisotopic Mass230.05791
SMILESC[C@H]1CC2=C(O1)c1cccc(O)c1C(=O)C2=O
InChIInChI=1S/C13H10O4/c1-6-5-8-11(15)12(16)10-7(13(8)17-6)3-2-4-9(10)14/h2-4,6,14H,5H2,1H3/t6-/m0/s1
InChIKeyFTSDAQTXFRWHEN-LURJTMIESA-N
Species of MetaboliteComponentSourceComments
Norcardia (ncbitaxon:1817) - PubMed (10866214) Strain: TC A0248
Roles Classification
Biological Roles:
antimicrobial agent  A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor  An EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor which interferes with the activity of the enzyme protein tyrosine phosphatases (PTPs), EC 3.1.3.48, involved in the removal of phosphate groups from phosphorylated tyrosine residues on proteins.
antifungal agent  An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce.
metabolite  Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
ChEBI Ontology
Outgoing Relation(s)
nocardione A (CHEBI:66634) has role antifungal agent (CHEBI:35718)
nocardione A (CHEBI:66634) has role antimicrobial agent (CHEBI:33281)
nocardione A (CHEBI:66634) has role EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor (CHEBI:35608)
nocardione A (CHEBI:66634) has role metabolite (CHEBI:25212)
nocardione A (CHEBI:66634) is a naphthofuran (CHEBI:39270)
nocardione A (CHEBI:66634) is a orthoquinones (CHEBI:25622)
nocardione A (CHEBI:66634) is a phenols (CHEBI:33853)
IUPAC Name 
(2S)-6-hydroxy-2-methyl-2,3-dihydronaphtho[1,2-b]furan-4,5-dione
Synonym  Source
(S)-(−)-nocardione AChEBI
Registry NumbersSources
Reaxys:9061138Reaxys
Citations