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CHEBI:65895 - fattiviracin A1

ChEBI IDCHEBI:65895
ChEBI Namefattiviracin A1
Stars
DefinitionA carbohydrate-containing antibiotic isolated from the fermentation broth of Streptomyces microflavus strain No. 2445 and exhibits antiviral activity against herpes simplex virus type 1 (HSV-1), varicella-zoster virus (VZV), influenza A virus and human immunodeficiency virus type 1 (HIV-1).
Last Modified2 December 2019
DownloadsMolfile
FormulaC81H150O28
Net Charge0
Average Mass1572.063
Monoisotopic Mass1571.03136
SMILESCC(O)CCCCCCCCCCCCCCC(CCCCCCCCCCCCCC1CC(=O)OC[C@H]2O[C@@H](OC(CCCCCCCCCCCCCC(CCCCCC(C)O)O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)CC(=O)OC[C@H]3O[C@@H](O1)[C@H](O)[C@@H](O)[C@@H]3O)[C@H](O)[C@@H](O)[C@@H]2O)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
InChIInChI=1S/C81H150O28/c1-54(84)40-32-25-19-13-7-3-4-8-14-20-26-34-42-56(102-78-74(96)70(92)66(88)60(50-82)106-78)43-35-27-21-15-9-5-11-17-23-29-37-46-58-48-64(86)100-52-63-69(91)73(95)77(99)81(109-63)105-59(49-65(87)101-53-62-68(90)72(94)76(98)80(104-58)108-62)47-38-30-24-18-12-6-10-16-22-28-36-44-57(45-39-31-33-41-55(2)85)103-79-75(97)71(93)67(89)61(51-83)107-79/h54-63,66-85,88-99H,3-53H2,1-2H3/t54?,55?,56?,57?,58?,59?,60-,61-,62-,63-,66-,67-,68-,69-,70+,71+,72+,73+,74-,75-,76-,77-,78-,79-,80-,81-/m1/s1
InChIKeyYQYKMOMCJFNBBQ-MJSFJGRCSA-N
Species of MetaboliteComponentSourceComments
Streptomyces microflavus (ncbitaxon:1919) - PubMed (9918397) Strain: 2445
Roles Classification
Biological Roles:
anti-HSV-1 agent  An anti-HSV agent agent that destroys or inhibits the replication of herpes simplex virus-1.
EC 3.2.1.18 (exo-alpha-sialidase) inhibitor  An antiviral drug targeted at influenza viruses. Its mode of action consists of blocking the function of the viral neuraminidase protein (EC 3.2.1.18), thus preventing the virus from budding from the host cell.
anti-HIV-1 agent  An anti-HIV agent that destroys or inhibits the replication of HIV-1, the more infective and more virulent of the two types of HIV virus.
metabolite  Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
antimicrobial agent  A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
Application:
EC 3.2.1.18 (exo-alpha-sialidase) inhibitor  An antiviral drug targeted at influenza viruses. Its mode of action consists of blocking the function of the viral neuraminidase protein (EC 3.2.1.18), thus preventing the virus from budding from the host cell.
ChEBI Ontology
Outgoing Relation(s)
fattiviracin A1 (CHEBI:65895) has role anti-HIV-1 agent (CHEBI:64947)
fattiviracin A1 (CHEBI:65895) has role anti-HSV-1 agent (CHEBI:64953)
fattiviracin A1 (CHEBI:65895) has role EC 3.2.1.18 (exo-α-sialidase) inhibitor (CHEBI:52425)
fattiviracin A1 (CHEBI:65895) has role metabolite (CHEBI:25212)
fattiviracin A1 (CHEBI:65895) is a carbohydrate-containing antibiotic (CHEBI:23007)
fattiviracin A1 (CHEBI:65895) is a fatty acid derivative (CHEBI:61697)
fattiviracin A1 (CHEBI:65895) is a macrodiolide (CHEBI:145556)
fattiviracin A1 (CHEBI:65895) is a β-D-glucoside (CHEBI:22798)
Registry NumbersSources
Reaxys:8186205Reaxys
CAS:214417-77-3ChemIDplus
Citations