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CHEBI:6539 - Lorazepam

ChEBI IDCHEBI:6539
ChEBI NameLorazepam
Stars
Secondary ChEBI IDCHEBI:94326
Last Modified6 March 2017
DownloadsMolfile
FormulaC15H10Cl2N2O2
Net Charge0
Average Mass321.163
Monoisotopic Mass320.01193
SMILESO=C1Nc2ccc(Cl)cc2C(c2ccccc2Cl)=NC1O
InChIInChI=1S/C15H10Cl2N2O2/c16-8-5-6-12-10(7-8)13(19-15(21)14(20)18-12)9-3-1-2-4-11(9)17/h1-7,15,21H,(H,18,20)
InChIKeyDIWRORZWFLOCLC-UHFFFAOYSA-N
Roles Classification
Biological Role:
GABA modulator  A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
Application:
GABA modulator  A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
ChEBI Ontology
Outgoing Relation(s)
Lorazepam (CHEBI:6539) is a benzodiazepine (CHEBI:22720)
Synonyms  Source
LorazepamKEGG COMPOUND
Wy-4036DrugCentral
ativanDrugCentral
Wy 4036DrugCentral
Manual XrefsDatabases
D00365KEGG DRUG
LSM-4970LINCS
1606DrugCentral
HMDB0014332HMDB
Registry NumbersSources
CAS:846-49-1KEGG COMPOUND
CAS:846-49-1DrugCentral