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CHEBI:6539 - Lorazepam
| Formula | C15H10Cl2N2O2 |
| Net Charge | 0 |
| Average Mass | 321.163 |
| Monoisotopic Mass | 320.01193 |
| SMILES | O=C1Nc2ccc(Cl)cc2C(c2ccccc2Cl)=NC1O |
| InChI | InChI=1S/C15H10Cl2N2O2/c16-8-5-6-12-10(7-8)13(19-15(21)14(20)18-12)9-3-1-2-4-11(9)17/h1-7,15,21H,(H,18,20) |
| InChIKey | DIWRORZWFLOCLC-UHFFFAOYSA-N |
| Roles Classification |
|---|
| Biological Roles: | analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. GABA modulator A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act. |
| Applications: | anxiolytic drug Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. antidepressant Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. anticonvulsant A drug used to prevent seizures or reduce their severity. antipsychotic agent Antipsychotic drugs are agents that control agitated psychotic behaviour, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. GABA modulator A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| Lorazepam (CHEBI:6539) has role analgesic (CHEBI:35480) |
| Lorazepam (CHEBI:6539) has role anticonvulsant (CHEBI:35623) |
| Lorazepam (CHEBI:6539) has role antidepressant (CHEBI:35469) |
| Lorazepam (CHEBI:6539) has role antipsychotic agent (CHEBI:35476) |
| Lorazepam (CHEBI:6539) has role anxiolytic drug (CHEBI:35474) |
| Lorazepam (CHEBI:6539) is a benzodiazepine (CHEBI:22720) |
| Synonyms | Source |
|---|---|
| ativan | DrugCentral |
| Lorazepam | KEGG COMPOUND |
| Lorazepam civ | ChEMBL |
| NSC-289758 | ChEMBL |
| Wy 4036 | DrugCentral |
| Wy-4036 | DrugCentral |
| Brand Names | Source |
|---|---|
| Abbloraz | ChEMBL |
| Loraz | ChEMBL |
| Lorazepam intensol | ChEMBL |
| Lorazepam preservative free | ChEMBL |
| Loreev xr | ChEMBL |
| Temesta | ChEMBL |
| Manual Xrefs | Databases |
|---|---|
| 1606 | DrugCentral |
| D00365 | KEGG DRUG |
| HMDB0014332 | HMDB |
| LSM-4970 | LINCS |
| Registry Numbers | Sources |
|---|---|
| CAS:846-49-1 | DrugCentral |
| CAS:846-49-1 | KEGG COMPOUND |
| Citations |
|---|