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CHEBI:6539 - Lorazepam
| Formula | C15H10Cl2N2O2 |
| Net Charge | 0 |
| Average Mass | 321.163 |
| Monoisotopic Mass | 320.01193 |
| SMILES | O=C1Nc2ccc(Cl)cc2C(c2ccccc2Cl)=NC1O |
| InChI | InChI=1S/C15H10Cl2N2O2/c16-8-5-6-12-10(7-8)13(19-15(21)14(20)18-12)9-3-1-2-4-11(9)17/h1-7,15,21H,(H,18,20) |
| InChIKey | DIWRORZWFLOCLC-UHFFFAOYSA-N |
| Roles Classification |
|---|
| Biological Roles: | analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. GABA modulator A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act. |
| Applications: | antipsychotic agent Antipsychotic drugs are agents that control agitated psychotic behaviour, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. anticonvulsant A drug used to prevent seizures or reduce their severity. antidepressant Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. anxiolytic drug Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. GABA modulator A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| Lorazepam (CHEBI:6539) has role analgesic (CHEBI:35480) |
| Lorazepam (CHEBI:6539) has role anticonvulsant (CHEBI:35623) |
| Lorazepam (CHEBI:6539) has role antidepressant (CHEBI:35469) |
| Lorazepam (CHEBI:6539) has role antipsychotic agent (CHEBI:35476) |
| Lorazepam (CHEBI:6539) has role anxiolytic drug (CHEBI:35474) |
| Lorazepam (CHEBI:6539) is a benzodiazepine (CHEBI:22720) |
| Synonyms | Source |
|---|---|
| ativan | DrugCentral |
| Lorazepam | KEGG COMPOUND |
| Lorazepam civ | ChEMBL |
| NSC-289758 | ChEMBL |
| Wy 4036 | DrugCentral |
| Wy-4036 | DrugCentral |
| Brand Names | Source |
|---|---|
| Abbloraz | ChEMBL |
| Loraz | ChEMBL |
| Lorazepam intensol | ChEMBL |
| Lorazepam preservative free | ChEMBL |
| Loreev xr | ChEMBL |
| Temesta | ChEMBL |
| Manual Xrefs | Databases |
|---|---|
| 1606 | DrugCentral |
| D00365 | KEGG DRUG |
| HMDB0014332 | HMDB |
| LSM-4970 | LINCS |
| Registry Numbers | Sources |
|---|---|
| CAS:846-49-1 | DrugCentral |
| CAS:846-49-1 | KEGG COMPOUND |
| Citations |
|---|