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CHEBI:6532 - loperamide

Default Structure
ChEBI IDCHEBI:6532
ChEBI Nameloperamide
Stars
DefinitionA synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease.
Last Modified23 April 2020
DownloadsMolfile
FormulaC29H33ClN2O2
Net Charge0
Average Mass477.048
Monoisotopic Mass476.22306
SMILESCN(C)C(=O)C(CCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1
InChIInChI=1S/C29H33ClN2O2/c1-31(2)27(33)29(24-9-5-3-6-10-24,25-11-7-4-8-12-25)19-22-32-20-17-28(34,18-21-32)23-13-15-26(30)16-14-23/h3-16,34H,17-22H2,1-2H3
InChIKeyRDOIQAHITMMDAJ-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Roles:
mu-opioid receptor agonist  A compound that exhibits agonist activity at the μ-opioid receptor.
anticoronaviral agent  Any antiviral agent which inhibits the activity of coronaviruses.
Applications:
mu-opioid receptor agonist  A compound that exhibits agonist activity at the μ-opioid receptor.
antidiarrhoeal drug  Any drug found useful in the symptomatic treatment of diarrhoea.
ChEBI Ontology
Outgoing Relation(s)
loperamide (CHEBI:6532) has role anticoronaviral agent (CHEBI:149553)
loperamide (CHEBI:6532) has role antidiarrhoeal drug (CHEBI:55323)
loperamide (CHEBI:6532) has role μ-opioid receptor agonist (CHEBI:55322)
loperamide (CHEBI:6532) is a monocarboxylic acid amide (CHEBI:29347)
loperamide (CHEBI:6532) is a monochlorobenzenes (CHEBI:83403)
loperamide (CHEBI:6532) is a piperidines (CHEBI:26151)
loperamide (CHEBI:6532) is a tertiary alcohol (CHEBI:26878)
loperamide (CHEBI:6532) is conjugate base of loperamide(1+) (CHEBI:86969)
Incoming Relation(s)
loperamide(1+) (CHEBI:86969) is conjugate acid of loperamide (CHEBI:6532)
IUPAC Name 
4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide
INNs  Source
loperamidaChemIDplus
loperamideChemIDplus
loperamidumChemIDplus
Synonyms  Source
LoperamideKEGG COMPOUND
lopéramideWHO MedNet
Manual XrefsDatabases
1599DrugCentral
C07080KEGG COMPOUND
D08144KEGG DRUG
DB00836DrugBank
FR2100711Patent
HMDB0004999HMDB
LoperamideWikipedia
LSM-3365LINCS
US3714159Patent
Registry NumbersSources
Reaxys:1558273Reaxys
CAS:53179-11-6KEGG COMPOUND
CAS:53179-11-6ChemIDplus
Citations