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CHEBI:65310 - triciribine

ChEBI IDCHEBI:65310
ChEBI Nametriciribine
Stars
DefinitionA nucleoside analogue in which the nucleobase portion is a 1,4,5,6,8-pentaazaacenaphthylene ring system substituted with an amino group at position 3, and a methyl group at position 5 and is bound to the β-D-ribofuranosyl moiety by an N1-glycosidic linkage.
Last Modified25 February 2016
Submittermwilliams
DownloadsMolfile
FormulaC13H16N6O4
Net Charge0
Average Mass320.309
Monoisotopic Mass320.12330
SMILESCN1N=C(N)c2cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c3ncnc1c23
InChIInChI=1S/C13H16N6O4/c1-18-11-7-5(10(14)17-18)2-19(12(7)16-4-15-11)13-9(22)8(21)6(3-20)23-13/h2,4,6,8-9,13,20-22H,3H2,1H3,(H2,14,17)/t6-,8-,9-,13-/m1/s1
InChIKeyHOGVTUZUJGHKPL-HTVVRFAVSA-N
Roles Classification
Biological Role:
EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor  An inhibitor of phosphatidylinositol 3-kinase, EC 2.7.1.137, a family of related enzymes capable of phosphorylating the 3 position hydroxy group of the inositol ring of a phosphatidylinositol.
ChEBI Ontology
Outgoing Relation(s)
triciribine (CHEBI:65310) has role EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor (CHEBI:50914)
triciribine (CHEBI:65310) is a nucleoside analogue (CHEBI:60783)
IUPAC Name 
5-methyl-1-(β-D-ribofuranosyl)-1,5-dihydro-1,4,5,6,8-pentaazaacenaphthylen-3-amine
Synonym  Source
TCNNIST Chemistry WebBook
Manual XrefsDatabases
LSM-3810LINCS
Registry NumbersSources
Reaxys:1171593Reaxys
CAS:35943-35-2ChemIDplus
CAS:35943-35-2NIST Chemistry WebBook
Citations