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CHEBI:6439 - levobunolol hydrochloride

ChEBI IDCHEBI:6439
ChEBI Namelevobunolol hydrochloride
Stars
DefinitionA hydrochloride obtained by combining equimolar amounts of levobunolol and hydrochloric acid. A non-selective β-adrenergic antagonist used for treatment of glaucoma.
Last Modified15 May 2024
DownloadsMolfile
FormulaC17H25NO3.HCl
Net Charge0
Average Mass327.852
Monoisotopic Mass327.16012
SMILESCC(C)(C)NC[C@H](O)COc1cccc2c1CCCC2=O.Cl
InChIInChI=1S/C17H25NO3.ClH/c1-17(2,3)18-10-12(19)11-21-16-9-5-6-13-14(16)7-4-8-15(13)20;/h5-6,9,12,18-19H,4,7-8,10-11H2,1-3H3;1H/t12-;/m0./s1
InChIKeyDNTDOBSIBZKFCP-YDALLXLXSA-N
Roles Classification
Biological Role:
beta-adrenergic antagonist  An agent that binds to but does not activate β-adrenergic receptors thereby blocking the actions of endogenous or exogenous β-adrenergic agonists. β-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety.
Applications:
antiglaucoma drug  Any drug which can be used to prevent or alleviate glaucoma, a disease in which the optic nerve is damaged, resulting in progressive, irreversible loss of vision. It is often, though not always, associated with increased pressure of the fluid in the eye.
beta-adrenergic antagonist  An agent that binds to but does not activate β-adrenergic receptors thereby blocking the actions of endogenous or exogenous β-adrenergic agonists. β-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety.
ChEBI Ontology
Outgoing Relation(s)
levobunolol hydrochloride (CHEBI:6439) has part levobunolol(1+) (CHEBI:72567)
levobunolol hydrochloride (CHEBI:6439) has role antiglaucoma drug (CHEBI:39456)
levobunolol hydrochloride (CHEBI:6439) has role β-adrenergic antagonist (CHEBI:35530)
levobunolol hydrochloride (CHEBI:6439) is a hydrochloride (CHEBI:36807)
IUPAC Name 
5-[(2S)-3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydronaphthalen-1(2H)-one hydrochloride
Synonyms  Source
levobunolol hydrochlorideKEGG COMPOUND
(2S)-N-(tert-butyl)-2-hydroxy-3-[(5-oxo-5,6,7,8-tetrahydronaphthalen-1-yl)oxy]propan-1-aminium chlorideIUPAC
(−)-3,4-dihydro-5-(3-(tert-butylamino)-2-hydroxypropoxy)-1(2H)-naphthalenone hydrochlorideChemIDplus
levobunolol HClChemIDplus
(−)-5-(3-(tert-butylamino)-2-hydroxypropoxy)-3,4-dihydro-1(2H)-naphthalenone hydrochlorideChemIDplus
levobunolol monohydrochlorideChEBI
Brand Name  Source
BetaganKEGG DRUG
Manual XrefsDatabases
D01025KEGG DRUG
DBSALT000251DrugBank
US5733938Patent
US6159458Patent
WO2008002929Patent
WO2007034140Patent
CN101342163Patent
JP2008094780Patent
Registry NumbersSources
CAS:27912-14-7KEGG COMPOUND
CAS:27912-14-7ChemIDplus
Citations