memantine hydrochloride (CHEBI:64323)

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CHEBI:64323 - memantine hydrochloride

ChEBI ID	CHEBI:64323
ChEBI Name	memantine hydrochloride
Stars
Definition	A hydrochloride obtained by reaction of memantine with one equivalent of hydrochloric acid. A low to moderate affinity uncompetitive (open-channel); NMDA receptor antagonist which binds preferentially to the NMDA receptor-operated cation channels.
Last Modified	29 March 2012
Submitter	Steve
Downloads	Molfile

Formula	C12H21N.HCl
Net Charge	0
Average Mass	215.768
Monoisotopic Mass	215.14408
SMILES	CC12CC3CC(C)(C1)CC(N)(C3)C2.Cl
InChI	InChI=1S/C12H21N.ClH/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10;/h9H,3-8,13H2,1-2H3;1H
InChIKey	LDDHMLJTFXJGPI-UHFFFAOYSA-N

Roles Classification

Biological Roles:

NMDA receptor antagonist Any substance that inhibits the action of N-methyl-D-aspartate (NMDA) receptors. They tend to induce a state known as dissociative anesthesia, marked by catalepsy, amnesia, and analgesia, while side effects can include hallucinations, nightmares, and confusion. Due to their psychotomimetic effects, many NMDA receptor antagonists are used as recreational drugs.

dopaminergic agent A drug used for its effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons.

Applications:

antidepressant Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions.

antiparkinson drug A drug used in the treatment of Parkinson's disease.

dopaminergic agent A drug used for its effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons.

neuroprotective agent Any compound that can be used for the treatment of neurodegenerative disorders.

ChEBI Ontology

Outgoing Relation(s)
	memantine hydrochloride (CHEBI:64323) has part memantinium(1+) (CHEBI:64325)
	memantine hydrochloride (CHEBI:64323) has role anti-anaemic agent (CHEBI:75835)
	memantine hydrochloride (CHEBI:64323) has role antidepressant (CHEBI:35469)
	memantine hydrochloride (CHEBI:64323) has role antineoplastic agent (CHEBI:35610)
	memantine hydrochloride (CHEBI:64323) has role antiparkinson drug (CHEBI:48407)
	memantine hydrochloride (CHEBI:64323) has role dopaminergic agent (CHEBI:48560)
	memantine hydrochloride (CHEBI:64323) has role neuroprotective agent (CHEBI:63726)
	memantine hydrochloride (CHEBI:64323) has role NMDA receptor antagonist (CHEBI:60643)
	memantine hydrochloride (CHEBI:64323) is a hydrochloride (CHEBI:36807)
	memantine hydrochloride (CHEBI:64323) is a organic molecular entity (CHEBI:50860)
	memantine hydrochloride (CHEBI:64323) is a racemate (CHEBI:60911)

IUPAC Name
3,5-dimethyladamantan-1-amine hydrochloride

Synonyms	Source
1-Amino-3,5-dimethyladamantane hydrochloride	ChemIDplus
3,5-Dimethyl-1-adamantanamine hydrochloride	ChemIDplus
3,5-dimethyladamantan-1-aminium chloride	IUPAC
3,5-dimethyltricyclo(3.3.1.1^3,7)decan-1-amine hydrochloride	ChemIDplus
Acrescent	ChEMBL
Auxura	ChEMBL

Brand Names	Source
Akatinol	ChEMBL
Axura	ChEMBL
Marixino	ChEMBL
Marixino (previously maruxa)	ChEMBL
Memantine hydrochloride component of namzaric	ChEMBL
Namenda	KEGG DRUG

Manual Xrefs	Databases
D04905	KEGG DRUG
DB01043	DrugBank
US2011282100	Patent
WO2011125062	Patent

Registry Numbers	Sources
Reaxys:6573843	Reaxys
CAS:41100-52-1	ChemIDplus
CAS:41100-52-1	KEGG DRUG

Citations