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CHEBI:64207 - spiramide

ChEBI IDCHEBI:64207
ChEBI Namespiramide
Stars
DefinitionAn azaspiro compound that consists of 1,3,8-triazaspiro[4.5]decan-4-one having a phenyl group attached to N-1 and a 3-(4-fluorophenoxy)propyl attached to N-8. Selective 5-HT antagonist, which binds to 5-HT2 sites as potently as spiperone but has lower affinity for 5-HT2C receptors. Also a high affinity D2 receptor antagonist (Ki = 3 nM). Lacks the disruptive effect of spiperone on animal behaviour.
Last Modified25 February 2016
SubmitterSteve
DownloadsMolfile
FormulaC22H26FN3O2
Net Charge0
Average Mass383.467
Monoisotopic Mass383.20091
SMILESO=C1NCN(c2ccccc2)C12CCN(CCCOc1ccc(F)cc1)CC2
InChIInChI=1S/C22H26FN3O2/c23-18-7-9-20(10-8-18)28-16-4-13-25-14-11-22(12-15-25)21(27)24-17-26(22)19-5-2-1-3-6-19/h1-3,5-10H,4,11-17H2,(H,24,27)
InChIKeyFJUKDAZEABGEIH-UHFFFAOYSA-N
Wikipedia
Roles Classification
Chemical Role:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Roles:
dopaminergic antagonist  A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.
serotonergic antagonist  Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
Applications:
dopaminergic antagonist  A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.
serotonergic antagonist  Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
ChEBI Ontology
Outgoing Relation(s)
spiramide (CHEBI:64207) has role dopaminergic antagonist (CHEBI:48561)
spiramide (CHEBI:64207) has role serotonergic antagonist (CHEBI:48279)
spiramide (CHEBI:64207) is a aromatic ether (CHEBI:35618)
spiramide (CHEBI:64207) is a azaspiro compound (CHEBI:35624)
spiramide (CHEBI:64207) is a organofluorine compound (CHEBI:37143)
spiramide (CHEBI:64207) is a piperidines (CHEBI:26151)
spiramide (CHEBI:64207) is a tertiary amino compound (CHEBI:50996)
IUPAC Name 
8-[3-(4-fluorophenoxy)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
INNs  Source
espiramidaChemIDplus
spiramidumChemIDplus
spiramideChemIDplus
spiramideWHO MedNet
Synonym  Source
AMI-193ChEBI
Manual XrefsDatabases
US3238216Patent
SpiramideWikipedia
LSM-4124LINCS
Registry NumbersSources
Reaxys:631679Reaxys
CAS:510-74-7ChemIDplus
Citations