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CHEBI:64158 - 2-methyl-6-(phenylethynyl)pyridine hydrochloride

ChEBI IDCHEBI:64158
ChEBI Name2-methyl-6-(phenylethynyl)pyridine hydrochloride
Stars
DefinitionA hydrochloride salt obtained by reaction of 2-methyl-6-(phenylethynyl)pyridine with one equivalent of hydrochloric acid. Potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw.
Last Modified12 March 2012
SubmitterSteve
DownloadsMolfile
FormulaC14H11N.HCl
Net Charge0
Average Mass229.710
Monoisotopic Mass229.06583
SMILESCc1cccc(C#Cc2ccccc2)n1.Cl
InChIInChI=1S/C14H11N.ClH/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13;/h2-9H,1H3;1H
InChIKeyPKDHDJBNEKXCBI-UHFFFAOYSA-N
Roles Classification
Biological Role:
metabotropic glutamate receptor antagonist  An antagonist at the metabotropic glutamate receptor.
Application:
anxiolytic drug  Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions.
ChEBI Ontology
Outgoing Relation(s)
2-methyl-6-(phenylethynyl)pyridine hydrochloride (CHEBI:64158) has part 2-methyl-6-(phenylethynyl)pyridinium(1+) (CHEBI:64160)
2-methyl-6-(phenylethynyl)pyridine hydrochloride (CHEBI:64158) has role anxiolytic drug (CHEBI:35474)
2-methyl-6-(phenylethynyl)pyridine hydrochloride (CHEBI:64158) has role metabotropic glutamate receptor antagonist (CHEBI:63963)
2-methyl-6-(phenylethynyl)pyridine hydrochloride (CHEBI:64158) is a hydrochloride (CHEBI:36807)
IUPAC Name 
2-methyl-6-(phenylethynyl)pyridine hydrochloride
Synonyms  Source
MPEP hydrochlorideChEBI
2-methyl-6-(phenylethynyl)pyridinium chlorideIUPAC
6-methyl-2-(phenylethynyl)pyridine hydrochlorideChEBI
6-methyl-2-(phenylethynyl)pyridinium chlorideChEBI
Registry NumbersSources
Reaxys:9652435Reaxys
Citations