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CHEBI:64156 - imetit

ChEBI IDCHEBI:64156
ChEBI Nameimetit
Stars
DefinitionAn imidothiocarbamic ester that consists of isothiourea in which the thiol hydrogen is substituted by a 2-(imidazol-4-yl)ethyl group. An extremely potent, high affinity agonist at H3 and H4 receptors (Ki values are 0.3 and 2.7 nM respectively). Induces shape change in eosinophils with an EC50 of 25 nM. Centrally active following systemic administration.
Last Modified12 March 2012
SubmitterSteve
DownloadsMolfile
FormulaC6H10N4S
Net Charge0
Average Mass170.241
Monoisotopic Mass170.06262
SMILESN=C(N)SCCc1cncn1
InChIInChI=1S/C6H10N4S/c7-6(8)11-2-1-5-3-9-4-10-5/h3-4H,1-2H2,(H3,7,8)(H,9,10)
InChIKeyPEHSVUKQDJULKE-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Roles:
H4-receptor agonist  A histamine agonist that binds to and activates H4-receptors.
H3-receptor agonist  A histamine agonist that binds to and activates histamine H3-receptors.
Applications:
H4-receptor agonist  A histamine agonist that binds to and activates H4-receptors.
H3-receptor agonist  A histamine agonist that binds to and activates histamine H3-receptors.
ChEBI Ontology
Outgoing Relation(s)
imetit (CHEBI:64156) has role H3-receptor agonist (CHEBI:64154)
imetit (CHEBI:64156) has role H4-receptor agonist (CHEBI:64155)
imetit (CHEBI:64156) is a imidazoles (CHEBI:24780)
imetit (CHEBI:64156) is a imidothiocarbamic ester (CHEBI:38914)
imetit (CHEBI:64156) is conjugate base of imetit(2+) (CHEBI:64157)
Incoming Relation(s)
imetit(2+) (CHEBI:64157) is conjugate acid of imetit (CHEBI:64156)
IUPAC Name 
2-(1H-imidazol-4-yl)ethyl carbamimidothioate
Synonym  Source
S-(2-(4-Imidazolyl)ethyl)isothioureaChemIDplus
Manual XrefsDatabases
C17931KEGG COMPOUND
ImetitWikipedia
Registry NumbersSources
Reaxys:880781Reaxys
CAS:102203-18-9KEGG COMPOUND
CAS:102203-18-9ChemIDplus