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CHEBI:64151 - imetit dihydrobromide

ChEBI IDCHEBI:64151
ChEBI Nameimetit dihydrobromide
Stars
DefinitionA hydrobromide salt obtained by reaction of imetit with two equivalents of hydrobromic acid. An extremely potent, high affinity agonist at H3 and H4 receptors (Ki values are 0.3 and 2.7 nM respectively). Induces shape change in eosinophils with an EC50 of 25 nM. Centrally active following systemic administration.
Last Modified12 March 2012
SubmitterSteve
DownloadsMolfile
FormulaC6H10N4S.2HBr
Net Charge0
Average Mass332.065
Monoisotopic Mass329.91494
SMILESBr.Br.N=C(N)SCCc1cncn1
InChIInChI=1S/C6H10N4S.2BrH/c7-6(8)11-2-1-5-3-9-4-10-5;;/h3-4H,1-2H2,(H3,7,8)(H,9,10);2*1H
InChIKeyDOBOYMKCRRLTRF-UHFFFAOYSA-N
Roles Classification
Biological Roles:
H3-receptor agonist  A histamine agonist that binds to and activates histamine H3-receptors.
H4-receptor agonist  A histamine agonist that binds to and activates H4-receptors.
Applications:
H3-receptor agonist  A histamine agonist that binds to and activates histamine H3-receptors.
H4-receptor agonist  A histamine agonist that binds to and activates H4-receptors.
ChEBI Ontology
Outgoing Relation(s)
imetit dihydrobromide (CHEBI:64151) has part imetit(2+) (CHEBI:64157)
imetit dihydrobromide (CHEBI:64151) has role H3-receptor agonist (CHEBI:64154)
imetit dihydrobromide (CHEBI:64151) has role H4-receptor agonist (CHEBI:64155)
imetit dihydrobromide (CHEBI:64151) is a hydrobromide (CHEBI:48367)
IUPAC Name 
2-(1H-imidazol-4-yl)ethyl carbamimidothioate dihydrobromide
Synonyms  Source
imetit hydrobromideChEBI
S-{2-[1H-imidazol-4-yl]ethyl}isothiourea dihydrobromideChEBI
Registry NumbersSources
Reaxys:5833853Reaxys
CAS:32385-58-3Reaxys