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CHEBI:64022 - nebivolol
| ChEBI ID | CHEBI:64022 |
| ChEBI Name | nebivolol |
| Stars | |
| Definition | A racemate consisting of equal amounts of (R,S,S,S)-nebivolol and (S,R,R,R)-nebivolol. A cardioselective beta blocker, it has vasodilatory activity but lacks intrinsic sympathomimetic and membrane-stabilising activity. It is used as the hydrochloride salt for the management of hypertension, and as an adjunct to standard therapy in elderly patients with stable chronic heart failure. |
| Last Modified | 26 October 2021 |
| Submitter | Gareth Owen |
| Wikipedia |
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| Roles Classification |
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| Biological Role: | beta-adrenergic antagonist An agent that binds to but does not activate β-adrenergic receptors thereby blocking the actions of endogenous or exogenous β-adrenergic agonists. β-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety. |
| Applications: | beta-adrenergic antagonist An agent that binds to but does not activate β-adrenergic receptors thereby blocking the actions of endogenous or exogenous β-adrenergic agonists. β-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety. vasodilator agent A drug used to cause dilation of the blood vessels. geroprotector Any compound that supports healthy aging, slows the biological aging process, or extends lifespan. antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. |
| ChEBI Ontology |
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| Outgoing Relation(s) |
| nebivolol (CHEBI:64022) has part (R,S,S,S)-nebivolol (CHEBI:64020) |
| nebivolol (CHEBI:64022) has part (S,R,R,R)-nebivolol (CHEBI:64021) |
| nebivolol (CHEBI:64022) has role antihypertensive agent (CHEBI:35674) |
| nebivolol (CHEBI:64022) has role geroprotector (CHEBI:176497) |
| nebivolol (CHEBI:64022) has role vasodilator agent (CHEBI:35620) |
| nebivolol (CHEBI:64022) has role β-adrenergic antagonist (CHEBI:35530) |
| nebivolol (CHEBI:64022) is a racemate (CHEBI:60911) |
| INNs | Source |
|---|---|
| nebivolol | ChemIDplus |
| nebivololum | ChEBI |
| Synonyms | Source |
|---|---|
| (1RS,1'RS)-1,1'-[(2RS,2'SR)-bis(6-fluorochroman-2-yl)]-2,2'-iminodiethanol | ChEBI |
| (1RS,1'RS)-2,2'-iminobis{1-[(2RS,2'SR)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]ethanol} | ChEBI |
| dl-nebivolol | ChemIDplus |
| Registry Numbers | Sources |
|---|---|
| Reaxys:4789059 | Reaxys |
| CAS:118457-14-0 | ChemIDplus |
| Citations |
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