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CHEBI:64022 - nebivolol
| ChEBI ID | CHEBI:64022 |
| ChEBI Name | nebivolol |
| Stars | |
| Definition | A racemate consisting of equal amounts of (R,S,S,S)-nebivolol and (S,R,R,R)-nebivolol. A cardioselective beta blocker, it has vasodilatory activity but lacks intrinsic sympathomimetic and membrane-stabilising activity. It is used as the hydrochloride salt for the management of hypertension, and as an adjunct to standard therapy in elderly patients with stable chronic heart failure. |
| Last Modified | 26 October 2021 |
| Submitter | Gareth Owen |
| Wikipedia |
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| Roles Classification |
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| Biological Role: | beta-adrenergic antagonist An agent that binds to but does not activate β-adrenergic receptors thereby blocking the actions of endogenous or exogenous β-adrenergic agonists. β-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety. |
| Applications: | antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. vasodilator agent A drug used to cause dilation of the blood vessels. geroprotector Any compound that supports healthy aging, slows the biological aging process, or extends lifespan. beta-adrenergic antagonist An agent that binds to but does not activate β-adrenergic receptors thereby blocking the actions of endogenous or exogenous β-adrenergic agonists. β-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety. |
| ChEBI Ontology |
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| Outgoing Relation(s) |
| nebivolol (CHEBI:64022) has part (R,S,S,S)-nebivolol (CHEBI:64020) |
| nebivolol (CHEBI:64022) has part (S,R,R,R)-nebivolol (CHEBI:64021) |
| nebivolol (CHEBI:64022) has role antihypertensive agent (CHEBI:35674) |
| nebivolol (CHEBI:64022) has role geroprotector (CHEBI:176497) |
| nebivolol (CHEBI:64022) has role vasodilator agent (CHEBI:35620) |
| nebivolol (CHEBI:64022) has role β-adrenergic antagonist (CHEBI:35530) |
| nebivolol (CHEBI:64022) is a racemate (CHEBI:60911) |
| INNs | Source |
|---|---|
| nebivolol | ChemIDplus |
| nebivololum | ChEBI |
| Synonyms | Source |
|---|---|
| (1RS,1'RS)-2,2'-iminobis{1-[(2RS,2'SR)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]ethanol} | ChEBI |
| dl-nebivolol | ChemIDplus |
| (1RS,1'RS)-1,1'-[(2RS,2'SR)-bis(6-fluorochroman-2-yl)]-2,2'-iminodiethanol | ChEBI |
| Registry Numbers | Sources |
|---|---|
| Reaxys:4789059 | Reaxys |
| CAS:118457-14-0 | ChemIDplus |
| Citations |
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