EMBL-EBI | Chemical Biology | ChEBI

Example searches: iron*, InChI=1S/CH4O/c1-2/h2H,1H3, caffeine | Advanced Search

CHEBI:63791 - lenalidomide

ChEBI IDCHEBI:63791
ChEBI Namelenalidomide
Stars
DefinitionA dicarboximide that consists of 1-oxoisoindoline bearing an amino substituent at position 4 and a 2,6-dioxopiperidin-3-yl group at position 2. Inhibits the secretion of TNF-α.
Last Modified22 February 2017
DownloadsMolfile
FormulaC13H13N3O3
Net Charge0
Average Mass259.265
Monoisotopic Mass259.09569
SMILESNc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O
InChIInChI=1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18)
InChIKeyGOTYRUGSSMKFNF-UHFFFAOYSA-N
Wikipedia
Roles Classification
Chemical Role:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Role:
immunomodulator  Biologically active substance whose activity affects or plays a role in the functioning of the immune system.
Applications:
immunomodulator  Biologically active substance whose activity affects or plays a role in the functioning of the immune system.
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
angiogenesis inhibitor  An agent and endogenous substances that antagonize or inhibit the development of new blood vessels.
ChEBI Ontology
Outgoing Relation(s)
lenalidomide (CHEBI:63791) has role angiogenesis inhibitor (CHEBI:48422)
lenalidomide (CHEBI:63791) has role antineoplastic agent (CHEBI:35610)
lenalidomide (CHEBI:63791) has role immunomodulator (CHEBI:50846)
lenalidomide (CHEBI:63791) is a aromatic amine (CHEBI:33860)
lenalidomide (CHEBI:63791) is a dicarboximide (CHEBI:35356)
lenalidomide (CHEBI:63791) is a isoindoles (CHEBI:24897)
lenalidomide (CHEBI:63791) is a piperidones (CHEBI:48589)
IUPAC Name 
3-(4-amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione
INN  Source
lenalidomideKEGG DRUG
Synonyms  Source
3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dioneChemIDplus
1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindolineChEBI
Brand Name  Source
RevlimidKEGG DRUG
Manual XrefsDatabases
D04687KEGG DRUG
DB00480DrugBank
LenalidomideWikipedia
LSM-6187LINCS
3317DrugCentral
Registry NumbersSources
Reaxys:8335210Reaxys
CAS:191732-72-6ChemIDplus
Citations