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CHEBI:63718 - tenofovir disoproxil fumarate
| Formula | C19H30N5O10P.C4H4O4 |
| Net Charge | 0 |
| Average Mass | 635.520 |
| Monoisotopic Mass | 635.18399 |
| SMILES | CC(C)OC(=O)OCOP(=O)(CO[C@H](C)Cn1cnc2c(N)ncnc21)OCOC(=O)OC(C)C.O=C(O)/C=C/C(=O)O |
| InChI | InChI=1S/C19H30N5O10P.C4H4O4/c1-12(2)33-18(25)28-9-31-35(27,32-10-29-19(26)34-13(3)4)11-30-14(5)6-24-8-23-15-16(20)21-7-22-17(15)24;5-3(6)1-2-4(7)8/h7-8,12-14H,6,9-11H2,1-5H3,(H2,20,21,22);1-2H,(H,5,6)(H,7,8)/b;2-1+/t14-;/m1./s1 |
| InChIKey | VCMJCVGFSROFHV-WZGZYPNHSA-N |
| Wikipedia |
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| Roles Classification |
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| Biological Roles: | antiviral drug A substance used in the prophylaxis or therapy of virus diseases. anti-HIV agent An antiviral agent that destroys or inhibits the replication of the human immunodeficiency virus. HIV-1 reverse transcriptase inhibitor An entity which inhibits the activity of HIV-1 reverse transcriptase. antiviral agent A substance that destroys or inhibits replication of viruses. antitubercular agent A substance that kills or slows the growth of Mycobacterium tuberculosis and is used in the treatment of tuberculosis. anti-HBV agent An antiviral agent that destroys or inhibits the replication of the hepatitis B virus. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. insulin-sensitizing drug An agent which overcomes insulin resistance by activation of the peroxisome proliferator activated receptor gamma (PPAR-gamma). |
| Applications: | antiinfective agent A substance used in the prophylaxis or therapy of infectious diseases. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. antiviral drug A substance used in the prophylaxis or therapy of virus diseases. antitubercular agent A substance that kills or slows the growth of Mycobacterium tuberculosis and is used in the treatment of tuberculosis. prodrug A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. antiparkinson drug A drug used in the treatment of Parkinson's disease. insulin-sensitizing drug An agent which overcomes insulin resistance by activation of the peroxisome proliferator activated receptor gamma (PPAR-gamma). |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| tenofovir disoproxil fumarate (CHEBI:63718) has part tenofovir disoproxil (CHEBI:63717) |
| tenofovir disoproxil fumarate (CHEBI:63718) has role anti-HBV agent (CHEBI:64951) |
| tenofovir disoproxil fumarate (CHEBI:63718) has role anti-HIV agent (CHEBI:64946) |
| tenofovir disoproxil fumarate (CHEBI:63718) has role antiinfective agent (CHEBI:35441) |
| tenofovir disoproxil fumarate (CHEBI:63718) has role antineoplastic agent (CHEBI:35610) |
| tenofovir disoproxil fumarate (CHEBI:63718) has role antiparkinson drug (CHEBI:48407) |
| tenofovir disoproxil fumarate (CHEBI:63718) has role antitubercular agent (CHEBI:33231) |
| tenofovir disoproxil fumarate (CHEBI:63718) has role antiviral agent (CHEBI:22587) |
| tenofovir disoproxil fumarate (CHEBI:63718) has role antiviral drug (CHEBI:36044) |
| tenofovir disoproxil fumarate (CHEBI:63718) has role HIV-1 reverse transcriptase inhibitor (CHEBI:53756) |
| tenofovir disoproxil fumarate (CHEBI:63718) has role immunosuppressive agent (CHEBI:35705) |
| tenofovir disoproxil fumarate (CHEBI:63718) has role insulin-sensitizing drug (CHEBI:50864) |
| tenofovir disoproxil fumarate (CHEBI:63718) has role prodrug (CHEBI:50266) |
| tenofovir disoproxil fumarate (CHEBI:63718) is a fumarate salt (CHEBI:50921) |
| IUPAC Name |
|---|
| bis({[(propan-2-yloxy)carbonyl]oxy}methyl) ({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)phosphonate (2E)-but-2-enedioate |
| Synonyms | Source |
|---|---|
| 9-((R)-2-((bis(((isopropoxycarbonyl)oxy)methoxy)phosphinyl)methoxy)propyl)adenine fumarate | ChemIDplus |
| GS-4331-05 | ChEMBL |
| GS-4331-05- | ChEMBL |
| GSK-548470 | ChEMBL |
| GSK548470 | ChEMBL |
| PMPA-PRODRUG | ChEMBL |
| Brand Names | Source |
|---|---|
| Tenofovir disoproxil fumarate component of atripla | ChEMBL |
| Tenofovir disoproxil fumarate component of cimduo | ChEMBL |
| Tenofovir disoproxil fumarate component of complera | ChEMBL |
| Tenofovir disoproxil fumarate component of delstrigo | ChEMBL |
| Tenofovir disoproxil fumarate component of eviplera | ChEMBL |
| Tenofovir disoproxil fumarate component of odefsey | ChEMBL |
| Registry Numbers | Sources |
|---|---|
| Reaxys:9831556 | Reaxys |
| CAS:202138-50-9 | ChemIDplus |
| Citations |
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