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CHEBI:63718 - tenofovir disoproxil fumarate
| Formula | C19H30N5O10P.C4H4O4 |
| Net Charge | 0 |
| Average Mass | 635.520 |
| Monoisotopic Mass | 635.18399 |
| SMILES | CC(C)OC(=O)OCOP(=O)(CO[C@H](C)Cn1cnc2c(N)ncnc21)OCOC(=O)OC(C)C.O=C(O)/C=C/C(=O)O |
| InChI | InChI=1S/C19H30N5O10P.C4H4O4/c1-12(2)33-18(25)28-9-31-35(27,32-10-29-19(26)34-13(3)4)11-30-14(5)6-24-8-23-15-16(20)21-7-22-17(15)24;5-3(6)1-2-4(7)8/h7-8,12-14H,6,9-11H2,1-5H3,(H2,20,21,22);1-2H,(H,5,6)(H,7,8)/b;2-1+/t14-;/m1./s1 |
| InChIKey | VCMJCVGFSROFHV-WZGZYPNHSA-N |
| Wikipedia |
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| Roles Classification |
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| Biological Roles: | antitubercular agent A substance that kills or slows the growth of Mycobacterium tuberculosis and is used in the treatment of tuberculosis. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. insulin-sensitizing drug An agent which overcomes insulin resistance by activation of the peroxisome proliferator activated receptor gamma (PPAR-gamma). anti-HBV agent An antiviral agent that destroys or inhibits the replication of the hepatitis B virus. anti-HIV agent An antiviral agent that destroys or inhibits the replication of the human immunodeficiency virus. antiviral drug A substance used in the prophylaxis or therapy of virus diseases. HIV-1 reverse transcriptase inhibitor An entity which inhibits the activity of HIV-1 reverse transcriptase. antiviral agent A substance that destroys or inhibits replication of viruses. |
| Applications: | prodrug A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug. antiparkinson drug A drug used in the treatment of Parkinson's disease. antiinfective agent A substance used in the prophylaxis or therapy of infectious diseases. antitubercular agent A substance that kills or slows the growth of Mycobacterium tuberculosis and is used in the treatment of tuberculosis. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. insulin-sensitizing drug An agent which overcomes insulin resistance by activation of the peroxisome proliferator activated receptor gamma (PPAR-gamma). antiviral drug A substance used in the prophylaxis or therapy of virus diseases. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| tenofovir disoproxil fumarate (CHEBI:63718) has part tenofovir disoproxil (CHEBI:63717) |
| tenofovir disoproxil fumarate (CHEBI:63718) has role anti-HBV agent (CHEBI:64951) |
| tenofovir disoproxil fumarate (CHEBI:63718) has role anti-HIV agent (CHEBI:64946) |
| tenofovir disoproxil fumarate (CHEBI:63718) has role antiinfective agent (CHEBI:35441) |
| tenofovir disoproxil fumarate (CHEBI:63718) has role antineoplastic agent (CHEBI:35610) |
| tenofovir disoproxil fumarate (CHEBI:63718) has role antiparkinson drug (CHEBI:48407) |
| tenofovir disoproxil fumarate (CHEBI:63718) has role antitubercular agent (CHEBI:33231) |
| tenofovir disoproxil fumarate (CHEBI:63718) has role antiviral agent (CHEBI:22587) |
| tenofovir disoproxil fumarate (CHEBI:63718) has role antiviral drug (CHEBI:36044) |
| tenofovir disoproxil fumarate (CHEBI:63718) has role HIV-1 reverse transcriptase inhibitor (CHEBI:53756) |
| tenofovir disoproxil fumarate (CHEBI:63718) has role immunosuppressive agent (CHEBI:35705) |
| tenofovir disoproxil fumarate (CHEBI:63718) has role insulin-sensitizing drug (CHEBI:50864) |
| tenofovir disoproxil fumarate (CHEBI:63718) has role prodrug (CHEBI:50266) |
| tenofovir disoproxil fumarate (CHEBI:63718) is a fumarate salt (CHEBI:50921) |
| IUPAC Name |
|---|
| bis({[(propan-2-yloxy)carbonyl]oxy}methyl) ({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)phosphonate (2E)-but-2-enedioate |
| Synonyms | Source |
|---|---|
| 9-((R)-2-((bis(((isopropoxycarbonyl)oxy)methoxy)phosphinyl)methoxy)propyl)adenine fumarate | ChemIDplus |
| GS-4331-05 | ChEMBL |
| GS-4331-05- | ChEMBL |
| GSK-548470 | ChEMBL |
| GSK548470 | ChEMBL |
| PMPA-PRODRUG | ChEMBL |
| Brand Names | Source |
|---|---|
| Tenofovir disoproxil fumarate component of atripla | ChEMBL |
| Tenofovir disoproxil fumarate component of cimduo | ChEMBL |
| Tenofovir disoproxil fumarate component of complera | ChEMBL |
| Tenofovir disoproxil fumarate component of delstrigo | ChEMBL |
| Tenofovir disoproxil fumarate component of eviplera | ChEMBL |
| Tenofovir disoproxil fumarate component of odefsey | ChEMBL |
| Registry Numbers | Sources |
|---|---|
| Reaxys:9831556 | Reaxys |
| CAS:202138-50-9 | ChemIDplus |
| Citations |
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