ivermectin (CHEBI:6078)

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CHEBI:6078 - ivermectin

ChEBI ID	CHEBI:6078
ChEBI Name	ivermectin
Stars
Definition	A mixture consisting of ≥ 90% 22,23-dihydroavermectin B_1a (R = Me) and ≤ 10% 22,23-dihydroavermectin B_1b (R = H). A semi-synthetic derivative of abamectin, it is used as a broad-spectrum antiparasite medication, particularly against worms (except tapeworms), although it is also effective against most mites and some lice.
Last Modified	23 November 2020
Downloads	Molfile

Formula	C47H71O14R
Net Charge	0
Average Mass (excl. R groups)	860.060
Monoisotopic Mass (excl. R groups)	859.48438
SMILES	*C[C@H](C)[C@@]1([H])O[C@]2(CC[C@@H]1C)C[C@@H]1C[C@@]([H])(C/C=C(\C)[C@@H](O[C@H]3C[C@H](OC)[C@@H](O[C@H]4C[C@H](OC)[C@@H](O)[C@H](C)O4)[C@H](C)O3)[C@@H](C)/C=C/C=C3\CO[C@]4([H])[C@H](O)C(C)=C[C@@]([H])(C(=O)O1)[C@]34O)O2

Wikipedia

Roles Classification

Biological Roles:

antimicrobial agent A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.

antiviral agent A substance that destroys or inhibits replication of viruses.

antileishmanial agent An antiprotozoal drug used to treat or prevent infections caused by protozoan parasites that belong to the genus Leishmania.

antiprotozoal drug Any antimicrobial drug which is used to treat or prevent protozoal infections.

antimalarial A drug used in the treatment of malaria. Antimalarials are usually classified on the basis of their action against Plasmodia at different stages in their life cycle in the human.

Applications:

dermatologic drug A drug used to treat or prevent skin disorders or for the routine care of skin.

antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms.

antiinfective agent A substance used in the prophylaxis or therapy of infectious diseases.

scabicide An acaricide that kills mites of the genus Sarcoptes.

insecticide Strictly, a substance intended to kill members of the class Insecta. In common usage, any substance used for preventing, destroying, repelling or controlling insects.

antileishmanial agent An antiprotozoal drug used to treat or prevent infections caused by protozoan parasites that belong to the genus Leishmania.

antinematodal drug A substance used in the treatment or control of nematode infestations.

antiprotozoal drug Any antimicrobial drug which is used to treat or prevent protozoal infections.

antimalarial A drug used in the treatment of malaria. Antimalarials are usually classified on the basis of their action against Plasmodia at different stages in their life cycle in the human.

anthelminthic drug Substance intended to kill parasitic worms (helminths).

ChEBI Ontology

Outgoing Relation(s)
	ivermectin (CHEBI:6078) has part 22,23-dihydroavermectin B_1a (CHEBI:63941)
	ivermectin (CHEBI:6078) has part 22,23-dihydroavermectin B_1b (CHEBI:63943)
	ivermectin (CHEBI:6078) has role anthelminthic drug (CHEBI:35443)
	ivermectin (CHEBI:6078) has role antiinfective agent (CHEBI:35441)
	ivermectin (CHEBI:6078) has role antileishmanial agent (CHEBI:70868)
	ivermectin (CHEBI:6078) has role antimalarial (CHEBI:38068)
	ivermectin (CHEBI:6078) has role antimicrobial agent (CHEBI:33281)
	ivermectin (CHEBI:6078) has role antinematodal drug (CHEBI:35444)
	ivermectin (CHEBI:6078) has role antineoplastic agent (CHEBI:35610)
	ivermectin (CHEBI:6078) has role antiprotozoal drug (CHEBI:35820)
	ivermectin (CHEBI:6078) has role antiviral agent (CHEBI:22587)
	ivermectin (CHEBI:6078) has role dermatologic drug (CHEBI:50177)
	ivermectin (CHEBI:6078) has role insecticide (CHEBI:24852)
	ivermectin (CHEBI:6078) has role scabicide (CHEBI:73333)
	ivermectin (CHEBI:6078) is a mixture (CHEBI:60004)

INNs	Source
ivermectin	ChemIDplus
ivermectina	WHO MedNet
ivermectine	ChemIDplus
ivermectino	ChemIDplus
ivermectinum	ChemIDplus

Synonyms	Source
22,23-dihydroabamectin	ChEMBL
22,23-dihydroavermectin b1	ChEMBL
22,23-dihydroavermectin b1a	ChEMBL
22,23-dihydro c-076b1	ChEMBL
Acarexx	ChEMBL
Bimectin	ChEMBL

Brand Names	Source
Heartguard	ChEMBL
Ivermax	ChEBI
Ivomec	ChemIDplus
Mectizan	DrugBank
Noromectin	ChEBI
Privermectin	ChEBI

Manual Xrefs	Databases
1455	VSDB
7988461	ChemSpider
D00804	KEGG DRUG
DB00602	DrugBank
ivermectin	Alan Wood's Pesticides
Ivermectin	Wikipedia
US4199569	Patent

Registry Numbers	Sources
CAS:70288-86-7	ChemIDplus
CAS:70288-86-7	KEGG COMPOUND

Citations